Helen Davies

Research interests

Publications

• Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-020-16142-7

• A practical guide for mutational signature analysis in hematological malignancies

  Nature Communications · 2019 · https://doi.org/10.1038/s41467-019-11037-8

• Genomic patterns of progression in smoldering multiple myeloma

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-05058-y

• HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

  Nature Medicine · 2017 · https://doi.org/10.1038/nm.4292

• Universal Patterns of Selection in Cancer and Somatic Tissues

  Cell · 2017 · https://doi.org/10.1016/j.cell.2017.09.042

• Mutational signatures of ionizing radiation in second malignancies

  Nature Communications · 2016 · https://doi.org/10.1038/ncomms12605

• Landscape of somatic mutations in 560 breast cancer whole-genome sequences

  Nature · 2016 · https://doi.org/10.1038/nature17676

• Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

  Science · 2014 · https://doi.org/10.1126/science.1251343

• Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

  eLife · 2014 · https://doi.org/10.7554/elife.02935

• Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2814

• Signatures of mutational processes in human cancer

  Nature · 2013 · https://doi.org/10.1038/nature12477

• Systematic identification of genomic markers of drug sensitivity in cancer cells

  Nature · 2012 · 10.1038/nature11005

• Mutational Processes Molding the Genomes of 21 Breast Cancers

  Cell · 2012 · 10.1016/j.cell.2012.04.024

• The landscape of cancer genes and mutational processes in breast cancer

  Nature · 2012 · 10.1038/nature11017

• The Life History of 21 Breast Cancers

  Cell · 2012 · 10.1016/j.cell.2012.04.023

• SomaticSF3B1Mutation in Myelodysplasia with Ring Sideroblasts

  New England Journal of Medicine · 2011 · 10.1056/nejmoa1103283

• Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

  Nature · 2011 · 10.1038/nature09639

• Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

  Nature · 2010 · 10.1038/nature08672

• Signatures of mutation and selection in the cancer genome

  Nature · 2010 · 10.1038/nature08768

• A small-cell lung cancer genome with complex signatures of tobacco exposure

  Nature · 2009 · 10.1038/nature08629

• Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

  Nature Genetics · 2009 · 10.1038/ng.349

• Patterns of somatic mutation in human cancer genomes

  Nature · 2007 · 10.1038/nature05610

• Somatic Mutations of the Protein Kinase Gene Family in Human Lung Cancer

  Cancer Research · 2005 · https://doi.org/10.1158/0008-5472.can-05-1855

• A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

  Nature Genetics · 2005 · https://doi.org/10.1038/ng1571

• Intragenic ERBB2 kinase mutations in tumours

  Nature · 2004 · 10.1038/431525b

• BRAF and RAS mutations in human lung cancer and melanoma.

  PubMed · 2002

• Mutations of the BRAF gene in human cancer

  Nature · 2002 · 10.1038/nature00766

Current projects

No projects listed.