Gordon Dougan

Research interests

Publications

• FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

  Nature · 2022 · https://doi.org/10.1038/s41586-022-05594-0

• Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

  Nature · 2022 · https://doi.org/10.1038/s41586-022-04474-x

• SARS-CoV-2 evolution during treatment of chronic infection

  Nature · 2021 · https://doi.org/10.1038/s41586-021-03291-y

• Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2

  Nature · 2021 · https://doi.org/10.1038/s41586-021-03739-1

• Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

  Nature · 2021 · https://doi.org/10.1038/s41586-021-03412-7

• Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease

  Immunity · 2021 · https://doi.org/10.1016/j.immuni.2021.05.010

• Rapid implementation of SARS-CoV-2 sequencing to investigate cases of health-care associated COVID-19: a prospective genomic surveillance study

  The Lancet Infectious Diseases · 2020 · https://doi.org/10.1016/s1473-3099(20)30562-4

• Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

  Nature Genetics · 2019 · https://doi.org/10.1038/s41588-019-0417-8

• Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response

  Nature Genetics · 2018 · https://doi.org/10.1038/s41588-018-0046-7

• The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-07370-z

• Emergence of an Extensively Drug-Resistant Salmonella enterica Serovar Typhi Clone Harboring a Promiscuous Plasmid Encoding Resistance to Fluoroquinolones and Third-Generation Cephalosporins

  mBio · 2018 · https://doi.org/10.1128/mbio.00105-18

• A novel ciprofloxacin-resistant subclade of H58 Salmonella Typhi is associated with fluoroquinolone treatment failure

  eLife · 2016 · https://doi.org/10.7554/elife.14003

• Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events

  Nature Genetics · 2015 · https://doi.org/10.1038/ng.3281

• Evidence for several waves of global transmission in the seventh cholera pandemic

  Nature · 2011 · 10.1038/nature10392

• Rapid Pneumococcal Evolution in Response to Clinical Interventions

  Science · 2011 · 10.1126/science.1198545

• Dysregulated Humoral Immunity to Nontyphoidal Salmonella in HIV-Infected African Adults

  Science · 2010 · https://doi.org/10.1126/science.1180346

• The porin OmpD from nontyphoidal Salmonella is a key target for a protective B1b cell antibody response

  Proceedings of the National Academy of Sciences · 2009 · https://doi.org/10.1073/pnas.0812431106

• Salmonella enterica Serovar Typhimurium Exploits Inflammation to Compete with the Intestinal Microbiota

  PLoS Biology · 2007 · 10.1371/journal.pbio.0050244

• Antimicrobial Drug Resistance of Salmonella enterica Serovar Typhi in Asia and Molecular Mechanism of Reduced Susceptibility to the Fluoroquinolones

  Antimicrobial Agents and Chemotherapy · 2007 · https://doi.org/10.1128/aac.00294-07

• The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome

  Nature Genetics · 2006 · 10.1038/ng1830

• Typhoid Fever

  New England Journal of Medicine · 2002 · 10.1056/nejmra020201

• Genome sequence of Yersinia pestis, the causative agent of plague

  Nature · 2001 · 10.1038/35097083

• Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18

  Nature · 2001 · 10.1038/35101607

Current projects

No projects listed.