David C. Rubinsztein

Research interests

Publications

• Autophagy in healthy aging and disease

  Nature Aging · 2021 · https://doi.org/10.1038/s43587-021-00098-4

• Autophagy in major human diseases

  The EMBO Journal · 2021 · https://doi.org/10.15252/embj.2021108863

• Analysis of shared heritability in common disorders of the brain

  Science · 2018 · https://doi.org/10.1126/science.aap8757

• Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

  Neuron · 2017 · 10.1016/j.neuron.2017.01.022

• Molecular definitions of autophagy and related processes

  The EMBO Journal · 2017 · https://doi.org/10.15252/embj.201796697

• Compromised autophagy and neurodegenerative diseases

  Nature reviews. Neuroscience · 2015 · 10.1038/nrn3961

• Autophagy in malignant transformation and cancer progression

  The EMBO Journal · 2015 · https://doi.org/10.15252/embj.201490784

• Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease

  PLoS ONE · 2014 · 10.1371/journal.pone.0094661

• Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

  Cell Death and Differentiation · 2014 · 10.1038/cdd.2014.137

• Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2802

• Autophagy modulation as a potential therapeutic target for diverse diseases

  Nature Reviews Drug Discovery · 2012 · 10.1038/nrd3802

• Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

  Cell Death and Differentiation · 2011 · https://doi.org/10.1038/cdd.2011.96

• TFEB Links Autophagy to Lysosomal Biogenesis

  Science · 2011 · https://doi.org/10.1126/science.1204592

• Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

  Nature Genetics · 2011 · 10.1038/ng.803

• Autophagy and Aging

  Cell · 2011 · 10.1016/j.cell.2011.07.030

• Lysosomal positioning coordinates cellular nutrient responses

  Nature Cell Biology · 2011 · 10.1038/ncb2204

• Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease

  PLoS ONE · 2010 · 10.1371/journal.pone.0013950

• Plasma membrane contributes to the formation of pre-autophagosomal structures

  Nature Cell Biology · 2010 · 10.1038/ncb2078

• Regulation of Mammalian Autophagy in Physiology and Pathophysiology

  Physiological Reviews · 2010 · 10.1152/physrev.00030.2009

• Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

  Nature Genetics · 2009 · https://doi.org/10.1038/ng.440

• Potential therapeutic applications of autophagy

  Nature Reviews Drug Discovery · 2007 · 10.1038/nrd2272

• The roles of intracellular protein-degradation pathways in neurodegeneration

  Nature · 2006 · 10.1038/nature05291

• Trehalose, a Novel mTOR-independent Autophagy Enhancer, Accelerates the Clearance of Mutant Huntingtin and α-Synuclein

  Journal of Biological Chemistry · 2006 · 10.1074/jbc.m609532200

• Lithium induces autophagy by inhibiting inositol monophosphatase

  The Journal of Cell Biology · 2005 · 10.1083/jcb.200504035

• Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

  Nature Genetics · 2004 · https://doi.org/10.1038/ng1362

• α-Synuclein Is Degraded by Both Autophagy and the Proteasome

  Journal of Biological Chemistry · 2003 · 10.1074/jbc.m300227200

Current projects

No projects listed.