Joseph C. Wu

Research interests

Publications

• Artificial intelligence in drug development

  Nature Medicine · 2025 · https://doi.org/10.1038/s41591-024-03434-4

• An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging

  Nature Aging · 2021 · 10.1038/s43587-021-00082-y

• COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives

  Nature Reviews Cardiology · 2020 · https://doi.org/10.1038/s41569-020-0413-9

• Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis

  Nature Medicine · 2019 · https://doi.org/10.1038/s41591-019-0512-5

• High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells

  Science Translational Medicine · 2017 · https://doi.org/10.1126/scitranslmed.aaf2584

• Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair

  Circulation · 2017 · https://doi.org/10.1161/circulationaha.116.024145

• Human induced pluripotent stem cell–derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity

  Nature Medicine · 2016 · https://doi.org/10.1038/nm.4087

• Induced pluripotent stem cell technology: a decade of progress

  Nature Reviews Drug Discovery · 2016 · https://doi.org/10.1038/nrd.2016.245

• Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes

  Circulation Research · 2015 · https://doi.org/10.1161/circresaha.117.305365

• Amyloid-β 11 C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials

  Neurology · 2015 · https://doi.org/10.1212/wnl.0000000000001877

• Chemically defined generation of human cardiomyocytes

  Nature Methods · 2014 · https://doi.org/10.1038/nmeth.2999

• Global Epigenomic Reconfiguration During Mammalian Brain Development

  Science · 2013 · 10.1126/science.1237905

• Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies

  Nature Medicine · 2013 · https://doi.org/10.1038/nm.3267

• Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells

  Cell stem cell · 2013 · https://doi.org/10.1016/j.stem.2012.10.010

• Drug Screening Using a Library of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Disease-Specific Patterns of Cardiotoxicity

  Circulation · 2013 · https://doi.org/10.1161/circulationaha.113.001883

• Patient-Specific Induced Pluripotent Stem Cells as a Model for Familial Dilated Cardiomyopathy

  Science Translational Medicine · 2012 · https://doi.org/10.1126/scitranslmed.3003552

• Production of De Novo Cardiomyocytes: Human Pluripotent Stem Cell Differentiation and Direct Reprogramming

  Cell stem cell · 2012 · https://doi.org/10.1016/j.stem.2011.12.013

• MicroRNA-210 as a Novel Therapy for Treatment of Ischemic Heart Disease

  Circulation · 2010 · https://doi.org/10.1161/circulationaha.109.928424

• A nonviral minicircle vector for deriving human iPS cells

  Nature Methods · 2010 · https://doi.org/10.1038/nmeth.1426

• Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells

  Proceedings of the National Academy of Sciences · 2009 · https://doi.org/10.1073/pnas.0908450106

• In Vivo Visualization of Embryonic Stem Cell Survival, Proliferation, and Migration After Cardiac Delivery

  Circulation · 2006 · https://doi.org/10.1161/circulationaha.105.588954

• Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

  Nature · 2000 · https://doi.org/10.1038/35050006

• Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase Inhibitor

  Science · 1990 · https://doi.org/10.1126/science.1701568

Current projects

No projects listed.