Manfred B. Lutz

Research interests

Publications

• Neurodegeneration by α-synuclein-specific T cells in AAV-A53T-α-synuclein Parkinson’s disease mice

  Brain Behavior and Immunity · 2022 · 10.1016/j.bbi.2022.01.007

• TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity

  Nature Communications · 2018 · 10.1038/s41467-018-05167-8

• Adenosine-generating ovarian cancer cells attract myeloid cells which differentiate into adenosine-generating tumor associated macrophages – a self-amplifying, CD39- and CD73-dependent mechanism for tumor immune escape

  Journal for ImmunoTherapy of Cancer · 2016 · 10.1186/s40425-016-0154-9

• Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

  The Journal of Experimental Medicine · 2016 · 10.1084/jem.20151563

• Increased Frequency of Myeloid-derived Suppressor Cells during Active Tuberculosis and after Recent Mycobacterium tuberculosis Infection Suppresses T-Cell Function

  American Journal of Respiratory and Critical Care Medicine · 2013 · 10.1164/rccm.201302-0249oc

• CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice

  Journal of Clinical Investigation · 2011 · 10.1172/jci44925

• Nomenclature of monocytes and dendritic cells in blood

  Blood · 2010 · https://doi.org/10.1182/blood-2010-02-258558

• Subsets, expansion and activation of myeloid-derived suppressor cells

  Medical Microbiology and Immunology · 2010 · 10.1007/s00430-010-0151-4

• Myeloid‐derived suppressor cell activation by combined LPS and IFN‐γ treatment impairs DC development

  European Journal of Immunology · 2009 · 10.1002/eji.200939486

• Skin-Derived Dendritic Cells Can Mediate Deletional Tolerance of Class I-Restricted Self-Reactive T Cells

  The Journal of Immunology · 2007 · 10.4049/jimmunol.179.7.4535

• The Conduit System Transports Soluble Antigens from the Afferent Lymph to Resident Dendritic Cells in the T Cell Area of the Lymph Node

  Immunity · 2005 · https://doi.org/10.1016/j.immuni.2004.11.013

• Myeloid dendritic cell precursors generated from bone marrow suppress T cell responses via cell contact and nitric oxide production in vitro

  European Journal of Immunology · 2005 · 10.1002/eji.200526172

• Prevention and Treatment of Experimental Autoimmune Encephalomyelitis by Soluble CD83

  The Journal of Experimental Medicine · 2004 · 10.1084/jem.20030973

• Human CD4+CD25+ Regulatory, Contact-dependent T Cells Induce Interleukin 10–producing, Contact-independent Type 1-like Regulatory T Cells

  The Journal of Experimental Medicine · 2002 · 10.1084/jem.20020642

• Differential Functions of IL-4 Receptor Types I and II for Dendritic Cell Maturation and IL-12 Production and Their Dependency on GM-CSF

  The Journal of Immunology · 2002 · 10.4049/jimmunol.169.7.3574

• Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?

  Trends in Immunology · 2002 · https://doi.org/10.1016/s1471-4906(02)02281-0

• Matrix Metalloproteinases 9 and 2 Are Necessary for the Migration of Langerhans Cells and Dermal Dendritic Cells from Human and Murine Skin

  The Journal of Immunology · 2002 · 10.4049/jimmunol.168.9.4361

• The Production of IFN-γ by IL-12/IL-18-Activated Macrophages Requires STAT4 Signaling and Is Inhibited by IL-4

  The Journal of Immunology · 2001 · 10.4049/jimmunol.166.5.3075

• Repetitive Injections of Dendritic Cells Matured with Tumor Necrosis Factor α Induce Antigen-specific Protection of Mice from Autoimmunity

  The Journal of Experimental Medicine · 2001 · 10.1084/jem.20011341

• Culture of bone marrow cells in GM-CSF plus high doses of lipopolysaccharide generates exclusively immature dendritic cells which induce alloantigen- specific CD4 T cell anergyin vitro

  European Journal of Immunology · 2000 · 10.1002/(sici)1521-4141(200004)30:4<1048::aid-immu1048>3.0.co;2-w

• Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survivalin vivo

  European Journal of Immunology · 2000 · 10.1002/1521-4141(200007)30:7<1813::aid-immu1813>3.0.co;2-8

• Migration of Langerhans cells and dermal dendritic cells in skin organ cultures: augmentation by TNF-α and IL-1 β

  Journal of Leukocyte Biology · 1999 · https://doi.org/10.1002/jlb.66.3.462

• An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow

  Journal of Immunological Methods · 1999 · https://doi.org/10.1016/s0022-1759(98)00204-x

• Intracellular routes and selective retention of antigens in mildly acidic cathepsin D/lysosome-associated membrane protein-1/MHC class II-positive vesicles in immature dendritic cells

  The Journal of Immunology · 1997 · 10.4049/jimmunol.159.8.3707

• Dendritic cells process exogenous viral proteins and virus‐like particles for class I presentation to CD8+ cytotoxic T lymphocytes

  European Journal of Immunology · 1996 · 10.1002/eji.1830261109

Current projects

No projects listed.