Patrizia Mecocci

Research interests

Publications

• The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's disease

  Alzheimer s & Dementia · 2021 · 10.1002/alz.12283

• Common brain disorders are associated with heritable patterns of apparent aging of the brain

  Nature Neuroscience · 2019 · https://doi.org/10.1038/s41593-019-0471-7

• A Long Journey into Aging, Brain Aging, and Alzheimer’s Disease Following the Oxidative Stress Tracks

  Journal of Alzheimer s Disease · 2018 · 10.3233/jad-170732

• Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

  Nature Genetics · 2017 · https://doi.org/10.1038/ng.3916

• Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study

  Alzheimer s & Dementia · 2017 · 10.1016/j.jalz.2017.09.007

• Prevalence and prognosis of Alzheimer’s disease at the mild cognitive impairment stage

  Brain · 2015 · 10.1093/brain/awv029

• Mild cognitive impairment and deficits in instrumental activities of daily living: a systematic review

  Alzheimer s Research & Therapy · 2015 · https://doi.org/10.1186/s13195-015-0099-0

• Clinical trials and late‐stage drug development for A lzheimer's disease: an appraisal from 1984 to 2014

  Journal of Internal Medicine · 2014 · 10.1111/joim.12191

• Random Forest ensembles for detection and prediction of Alzheimer's disease with a good between-cohort robustness

  NeuroImage Clinical · 2014 · 10.1016/j.nicl.2014.08.023

• Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease

  Neurobiology of Aging · 2013 · 10.1016/j.neurobiolaging.2013.08.001

• Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2802

• Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease

  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2011 · 10.1016/j.bbadis.2011.10.006

• Alzheimer's disease: clinical trials and drug development

  The Lancet Neurology · 2010 · https://doi.org/10.1016/s1474-4422(10)70119-8

• Association of Plasma Clusterin Concentration With Severity, Pathology, and Progression in Alzheimer Disease

  Archives of General Psychiatry · 2010 · 10.1001/archgenpsychiatry.2010.78

• Neuropsychiatric Syndromes in Dementia

  Dementia and Geriatric Cognitive Disorders · 2007 · 10.1159/000110738

• Potential markers of oxidative stress in stroke

  Free Radical Biology and Medicine · 2005 · 10.1016/j.freeradbiomed.2005.06.025

• Oxidative stress in brain aging, neurodegenerative and vascular diseases: An overview

  Journal of Chromatography B · 2005 · 10.1016/j.jchromb.2005.04.023

• Validation of the Five‐Item Geriatric Depression Scale in Elderly Subjects in Three Different Settings

  Journal of the American Geriatrics Society · 2003 · 10.1034/j.1600-0579.2003.00216.x

• Marked Decrease in Plasma Antioxidants in Aged Osteoporotic Women: Results of a Cross-Sectional Study

  The Journal of Clinical Endocrinology & Metabolism · 2003 · 10.1210/jc.2002-021496

• Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer’s disease

  Neurobiology of Aging · 2003 · 10.1016/s0197-4580(03)00031-9

• Plasma antioxidants and longevity: a study on healthy centenarians

  Free Radical Biology and Medicine · 2000 · 10.1016/s0891-5849(00)00246-x

• Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle

  Free Radical Biology and Medicine · 1999 · 10.1016/s0891-5849(98)00208-1

• Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo

  Journal of Neuroscience · 1995 · 10.1523/jneurosci.15-12-08419.1995

• Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

  Annals of Neurology · 1994 · 10.1002/ana.410360510

• Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain

  Annals of Neurology · 1993 · 10.1002/ana.410340416

Current projects

No projects listed.