Gabriel Núñez

Research interests

Publications

• Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease

  Immunological Reviews · 2017 · 10.1111/imr.12567

• In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

  Cell · 2016 · https://doi.org/10.1016/j.cell.2016.11.052

• Mechanism and Regulation of NLRP3 Inflammasome Activation

  Trends in Biochemical Sciences · 2016 · 10.1016/j.tibs.2016.09.002

• NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

  Nature · 2016 · 10.1038/nature16959

• A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

  Nature Medicine · 2015 · https://doi.org/10.1038/nm.3806

• Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells

  Cell · 2015 · https://doi.org/10.1016/j.cell.2015.08.058

• Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

  Cell Death and Differentiation · 2014 · https://doi.org/10.1038/cdd.2014.137

• K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

  Immunity · 2013 · 10.1016/j.immuni.2013.05.016

• Role of the gut microbiota in immunity and inflammatory disease

  Nature reviews. Immunology · 2013 · 10.1038/nri3430

• Control of pathogens and pathobionts by the gut microbiota

  Nature Immunology · 2013 · 10.1038/ni.2608

• Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

  Cell Death and Differentiation · 2011 · https://doi.org/10.1038/cdd.2011.96

• Sterile inflammation: sensing and reacting to damage

  Nature reviews. Immunology · 2010 · 10.1038/nri2873

• Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

  Nature Immunology · 2009 · 10.1038/ni.1823

• The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

  Nature Immunology · 2009 · 10.1038/ni.1703

• Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

  Cell Death and Differentiation · 2008 · 10.1038/cdd.2008.150

• Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

  Nature · 2006 · 10.1038/nature04517

• Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

  Nature Immunology · 2006 · 10.1038/ni1346

• Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract

  Science · 2005 · 10.1126/science.1104911

• Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2

  Journal of Biological Chemistry · 2003 · 10.1074/jbc.c200673200

• An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

  Nature Immunology · 2003 · 10.1038/ni945

• A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

  Nature · 2001 · 10.1038/35079114

• Nod2, a Nod1/Apaf-1 Family Member That Is Restricted to Monocytes and Activates NF-κB

  Journal of Biological Chemistry · 2001 · 10.1074/jbc.m008072200

• Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

  Immunity · 1999 · 10.1016/s1074-7613(00)80011-4

• Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

  Science · 1997 · 10.1126/science.278.5338.687

• bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

  Cell · 1993 · 10.1016/0092-8674(93)90508-n

• Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

  Nature · 1990 · 10.1038/348334a0

• bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

  Cell · 1989 · 10.1016/0092-8674(89)90174-8

Current projects

No projects listed.