Johannes Kettunen

Research interests

Publications

• FinnGen provides genetic insights from a well-phenotyped isolated population

  Nature · 2023 · https://doi.org/10.1038/s41586-022-05473-8

• The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions

  Nature Genetics · 2023 · 10.1038/s41588-023-01323-z

• FinnGen: Unique genetic insights from combining isolated population and national health register data

  medRxiv · 2022 · 10.1101/2022.03.03.22271360

• Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

  Nature Genetics · 2021 · https://doi.org/10.1038/s41588-021-00913-z

• A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

  Nature Communications · 2019 · 10.1038/s41467-019-11311-9

• Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

  Nature Communications · 2019 · 10.1038/s41467-019-10936-0

• Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-04951-w

• Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-04558-1

• Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis

  bioRxiv (Cold Spring Harbor Laboratory) · 2018 · https://doi.org/10.1101/447367

• Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation Potential

  Stem Cell Reports · 2016 · 10.1016/j.stemcr.2015.12.009

• Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

  Nature Communications · 2016 · 10.1038/ncomms11122

• Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors

  The American Journal of Human Genetics · 2016 · 10.1016/j.ajhg.2016.11.007

• Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

  Science · 2016 · 10.1126/science.aad3517

• Metabolite Profiling and Cardiovascular Event Risk

  Circulation · 2015 · 10.1161/circulationaha.114.013116

• The impact of low-frequency and rare variants on lipid levels

  Nature Genetics · 2015 · 10.1038/ng.3300

• Biomarker Profiling by Nuclear Magnetic Resonance Spectroscopy for the Prediction of All-Cause Mortality: An Observational Study of 17,345 Persons

  PLoS Medicine · 2014 · 10.1371/journal.pmed.1001606

• Common variants associated with plasma triglycerides and risk for coronary artery disease

  Nature Genetics · 2013 · 10.1038/ng.2795

• Discovery and refinement of loci associated with lipid levels

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2797

• Identification of seven loci affecting mean telomere length and their association with disease

  Nature Genetics · 2013 · 10.1038/ng.2528

• Systematic identification of trans eQTLs as putative drivers of known disease associations

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2756

• Genome-wide association study identifies multiple loci influencing human serum metabolite levels

  Nature Genetics · 2012 · 10.1038/ng.1073

• Metabolic Signatures of Insulin Resistance in 7,098 Young Adults

  Diabetes · 2012 · 10.2337/db11-1355

• Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels

  Circulation · 2011 · 10.1161/circulationaha.110.948570

• Hundreds of variants clustered in genomic loci and biological pathways affect human height

  Nature · 2010 · https://doi.org/10.1038/nature09410

• Sequence variants at CHRNB3–CHRNA6 and CYP2A6 affect smoking behavior

  Nature Genetics · 2010 · 10.1038/ng.573

Current projects

No projects listed.