Jean Paul Vonsattel

Research interests

Publications

• Plasma p‐tau181, p‐tau217, and other blood‐based Alzheimer's disease biomarkers in a multi‐ethnic, community study

  Alzheimer s & Dementia · 2021 · https://doi.org/10.1002/alz.12301

• Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-019-14279-8

• Single-nucleus RNA-seq identifies Huntington disease astrocyte states

  Acta Neuropathologica Communications · 2020 · https://doi.org/10.1186/s40478-020-0880-6

• Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-020-19737-2

• CAG Repeat Not Polyglutamine Length Determines Timing of Huntington’s Disease Onset

  Cell · 2019 · https://doi.org/10.1016/j.cell.2019.06.036

• Identification of Genetic Factors that Modify Clinical Onset of Huntington’s Disease

  Cell · 2015 · https://doi.org/10.1016/j.cell.2015.07.003

• MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration

  Nature Communications · 2014 · https://doi.org/10.1038/ncomms4633

• Primary age-related tauopathy (PART): a common pathology associated with human aging

  Acta Neuropathologica · 2014 · https://doi.org/10.1007/s00401-014-1349-0

• CGG Repeat-Associated Translation Mediates Neurodegeneration in Fragile X Tremor Ataxia Syndrome

  Neuron · 2013 · https://doi.org/10.1016/j.neuron.2013.03.026

• Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

  Human Molecular Genetics · 2012 · https://doi.org/10.1093/hmg/dds161

• Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

  Nature Genetics · 2010 · https://doi.org/10.1038/ng.536

• Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

  Nature Medicine · 2008 · https://doi.org/10.1038/nm.1868

• A critical evaluation of the Braak staging scheme for Parkinson's disease

  Annals of Neurology · 2008 · https://doi.org/10.1002/ana.21541

• Office of Rare Diseases Neuropathologic Criteria for Corticobasal Degeneration

  Journal of Neuropathology & Experimental Neurology · 2002 · https://doi.org/10.1093/jnen/61.11.935

• Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy

  Annals of Neurology · 2001 · https://doi.org/10.1002/ana.1009

• Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

  Nature · 1999 · https://doi.org/10.1038/20446

• Huntington Disease

  Journal of Neuropathology & Experimental Neurology · 1998 · https://doi.org/10.1097/00005072-199805000-00001

• Strain-Related Differences in Susceptibility to Transient Forebrain Ischemia in SV-129 and C57Black/6 Mice

  Stroke · 1997 · https://doi.org/10.1161/01.str.28.9.1805

• Huntingtin localization in brains of normal and Huntington's disease patients

  Annals of Neurology · 1997 · https://doi.org/10.1002/ana.410420411

• Apolipoprotein E ϵ4 and cerebral hemorrhage associated with amyloid angiopathy

  Annals of Neurology · 1995 · https://doi.org/10.1002/ana.410380219

• Rapid induction of Alzheimer A beta amyloid formation by zinc

  Science · 1994 · https://doi.org/10.1126/science.8073293

• Trinucleotide repeat length instability and age of onset in Huntington's disease

  Nature Genetics · 1993 · https://doi.org/10.1038/ng0893-387

• The clinical spectrum of cerebral amyloid angiopathy

  Neurology · 1993 · https://doi.org/10.1212/wnl.43.10.2073

• Decreased Neuronal and Increased Oligodendroglial Densities in Huntington's Disease Caudate Nucleus

  Journal of Neuropathology & Experimental Neurology · 1991 · https://doi.org/10.1097/00005072-199111000-00005

• Cerebral amyloid angiopathy without and with cerebral hemorrhages: A comparative histological study

  Annals of Neurology · 1991 · https://doi.org/10.1002/ana.410300503

Current projects

No projects listed.