Vilas Menon

Research interests

Publications

• Cell subtype-specific effects of genetic variation in the Alzheimer’s disease brain

  Nature Genetics · 2024 · 10.1038/s41588-024-01685-y

• Cellular communities reveal trajectories of brain ageing and Alzheimer’s disease

  Nature · 2024 · 10.1038/s41586-024-07871-6

• SenNet recommendations for detecting senescent cells in different tissues

  Nature Reviews Molecular Cell Biology · 2024 · 10.1038/s41580-024-00738-8

• A cellular taxonomy of the adult human spinal cord

  Neuron · 2023 · 10.1016/j.neuron.2023.01.007

• Multicellular communities are perturbed in the aging human brain and Alzheimer’s disease

  Nature Neuroscience · 2023 · 10.1038/s41593-023-01356-x

• Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders

  Nature Neuroscience · 2022 · 10.1038/s41593-022-01128-z

• TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A

  Nature · 2022 · https://doi.org/10.1038/s41586-022-04436-3

• A harmonized atlas of mouse spinal cord cell types and their spatial organization

  Nature Communications · 2021 · 10.1038/s41467-021-25125-1

• Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors

  Neuron · 2021 · 10.1016/j.neuron.2021.08.003

• Aging disrupts circadian gene regulation and function in macrophages

  Nature Immunology · 2021 · 10.1038/s41590-021-01083-0

• Single-nucleus RNA-seq identifies Huntington disease astrocyte states

  Acta Neuropathologica Communications · 2020 · 10.1186/s40478-020-0880-6

• Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-020-19737-2

• Behavioral state coding by molecularly defined paraventricular hypothalamic cell type ensembles

  Science · 2020 · 10.1126/science.abb2494

• Generalized leaky integrate-and-fire models classify multiple neuron types

  Nature Communications · 2018 · 10.1038/s41467-017-02717-4

• Distinct descending motor cortex pathways and their roles in movement

  Nature · 2018 · 10.1038/s41586-018-0642-9

• Shared and distinct transcriptomic cell types across neocortical areas

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0654-5

• Adult mouse cortical cell taxonomy revealed by single cell transcriptomics

  Nature Neuroscience · 2016 · https://doi.org/10.1038/nn.4216

• A Single-Cell Roadmap of Lineage Bifurcation in Human ESC Models of Embryonic Brain Development

  Cell stem cell · 2016 · 10.1016/j.stem.2016.09.011

• Canonical genetic signatures of the adult human brain

  Nature Neuroscience · 2015 · https://doi.org/10.1038/nn.4171

• A High-Resolution Spatiotemporal Atlas of Gene Expression of the Developing Mouse Brain

  Neuron · 2014 · 10.1016/j.neuron.2014.05.033

• CORTECON: A Temporal Transcriptome Analysis of In Vitro Human Cerebral Cortex Development from Human Embryonic Stem Cells

  Neuron · 2014 · 10.1016/j.neuron.2014.05.013

• Correlated Gene Expression and Target Specificity Demonstrate Excitatory Projection Neuron Diversity

  Cerebral Cortex · 2013 · 10.1093/cercor/bht243

• Synapse Distribution Suggests a Two-Stage Model of Dendritic Integration in CA1 Pyramidal Neurons

  Neuron · 2009 · 10.1016/j.neuron.2009.06.023

Current projects

No projects listed.