John F. Thompson

Research interests

Publications

• Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy

  Cancer Cell · 2019 · https://doi.org/10.1016/j.ccell.2019.01.003

• Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets

  Nature Communications · 2019 · https://doi.org/10.1038/s41467-019-11107-x

• CD103+ Tumor-Resident CD8+ T Cells Are Associated with Improved Survival in Immunotherapy-Naïve Melanoma Patients and Expand Significantly During Anti–PD-1 Treatment

  Clinical Cancer Research · 2018 · https://doi.org/10.1158/1078-0432.ccr-17-2257

• Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma

  New England Journal of Medicine · 2017 · https://doi.org/10.1056/nejmoa1613210

• Melanoma staging: Evidence‐based changes in the American Joint Committee on Cancer eighth edition cancer staging manual

  CA A Cancer Journal for Clinicians · 2017 · https://doi.org/10.3322/caac.21409

• Whole-genome landscapes of major melanoma subtypes

  Nature · 2017 · https://doi.org/10.1038/nature22071

• Acquired BRAF inhibitor resistance: A multicenter meta-analysis of the spectrum and frequencies, clinical behaviour, and phenotypic associations of resistance mechanisms

  European Journal of Cancer · 2015 · https://doi.org/10.1016/j.ejca.2015.08.022

• Increased MAPK reactivation in early resistance to dabrafenib/trametinib combination therapy of BRAF-mutant metastatic melanoma

  Nature Communications · 2014 · https://doi.org/10.1038/ncomms6694

• Final Trial Report of Sentinel-Node Biopsy versus Nodal Observation in Melanoma

  New England Journal of Medicine · 2014 · 10.1056/nejmoa1310460

• BRAF Inhibitor Resistance Mechanisms in Metastatic Melanoma: Spectrum and Clinical Impact

  Clinical Cancer Research · 2014 · https://doi.org/10.1158/1078-0432.ccr-13-3122

• PD ‐L1 expression in melanoma shows marked heterogeneity within and between patients: implications for anti‐ PD ‐1/ PD ‐ L 1 clinical trials

  Pigment Cell & Melanoma Research · 2014 · https://doi.org/10.1111/pcmr.12340

• Tumor-Infiltrating Lymphocyte Grade Is an Independent Predictor of Sentinel Lymph Node Status and Survival in Patients With Cutaneous Melanoma

  Journal of Clinical Oncology · 2012 · https://doi.org/10.1200/jco.2011.37.8539

• Immunohistochemistry Is Highly Sensitive and Specific for the Detection of V600E BRAF Mutation in Melanoma

  The American Journal of Surgical Pathology · 2012 · https://doi.org/10.1097/pas.0b013e31826485c0

• Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma

  Cell · 2012 · 10.1016/j.cell.2012.07.033

• Distinguishing Clinicopathologic Features of Patients with V600E and V600K BRAF -Mutant Metastatic Melanoma

  Clinical Cancer Research · 2012 · 10.1158/1078-0432.ccr-12-0052

• Prognostic and Clinicopathologic Associations of Oncogenic BRAF in Metastatic Melanoma

  Journal of Clinical Oncology · 2011 · 10.1200/jco.2010.32.4327

• Selective BRAF Inhibitors Induce Marked T-cell Infiltration into Human Metastatic Melanoma

  Clinical Cancer Research · 2011 · 10.1158/1078-0432.ccr-11-2479

• Prognostic Significance of Mitotic Rate in Localized Primary Cutaneous Melanoma: An Analysis of Patients in the Multi-Institutional American Joint Committee on Cancer Melanoma Staging Database

  Journal of Clinical Oncology · 2011 · https://doi.org/10.1200/jco.2010.31.5812

• Multivariate Analysis of Prognostic Factors Among 2,313 Patients With Stage III Melanoma: Comparison of Nodal Micrometastases Versus Macrometastases

  Journal of Clinical Oncology · 2010 · https://doi.org/10.1200/jco.2009.27.1627

• Final Version of 2009 AJCC Melanoma Staging and Classification

  Journal of Clinical Oncology · 2009 · https://doi.org/10.1200/jco.2009.23.4799

• Sentinel-Node Biopsy or Nodal Observation in Melanoma

  New England Journal of Medicine · 2006 · https://doi.org/10.1056/nejmoa060992

• Sentinel Node Biopsy for Early-Stage Melanoma

  Annals of Surgery · 2005 · 10.1097/01.sla.0000181092.50141.fa

• Determinants of Outcome in Melanoma Patients With Cerebral Metastases

  Journal of Clinical Oncology · 2004 · 10.1200/jco.2004.08.140

• Tumor mitotic rate is a more powerful prognostic indicator than ulceration in patients with primary cutaneous melanoma

  Cancer · 2003 · 10.1002/cncr.11196

• Psychological responses of patients receiving a diagnosis of cancer

  Annals of Oncology · 2002 · 10.1093/annonc/mdg010

• Final Version of the American Joint Committee on Cancer Staging System for Cutaneous Melanoma

  Journal of Clinical Oncology · 2001 · https://doi.org/10.1200/jco.2001.19.16.3635

• Prognostic Factors Analysis of 17,600 Melanoma Patients: Validation of the American Joint Committee on Cancer Melanoma Staging System

  Journal of Clinical Oncology · 2001 · https://doi.org/10.1200/jco.2001.19.16.3622

• A new American Joint Committee on Cancer staging system for cutaneous melanoma

  Cancer · 2000 · 10.1002/(sici)1097-0142(20000315)88:6<1484::aid-cncr29>3.0.co;2-d

• Validation of the Accuracy of Intraoperative Lymphatic Mapping and Sentinel Lymphadenectomy for Early-Stage Melanoma

  Annals of Surgery · 1999 · 10.1097/00000658-199910000-00001

• Sentinel lymph node status as an indicator of the presence of metastatic melanoma in regional lymph nodes

  Melanoma Research · 1995 · 10.1097/00008390-199508000-00008

Current projects

No projects listed.