Alexander C. Huang
Researcher Next ID · RN-028093
Researcher · Medicine
Hospital of the University of Pennsylvania
Philadelphia, Croatia
- Works count
- 206
- Citation count
- 20,575
- H-index
- 41
- i10-index
- 61
Research interests
Publications
Combined JAK inhibition and PD-1 immunotherapy for non–small cell lung cancer patients
Science · 2024 · https://doi.org/10.1126/science.adf1329
A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance
Nature Immunology · 2022 · https://doi.org/10.1038/s41590-022-01141-1
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics
Nature Immunology · 2022 · https://doi.org/10.1038/s41590-022-01338-4
CD8+ T cells contribute to survival in patients with COVID-19 and hematologic cancer
Nature Medicine · 2021 · https://doi.org/10.1038/s41591-021-01386-7
Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19
Science Immunology · 2021 · https://doi.org/10.1126/sciimmunol.abf7570
Pathological response and survival with neoadjuvant therapy in melanoma: a pooled analysis from the International Neoadjuvant Melanoma Consortium (INMC)
Nature Medicine · 2021 · https://doi.org/10.1038/s41591-020-01188-3
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
Science · 2020 · https://doi.org/10.1126/science.abc8511
Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
Immunity · 2020 · 10.1016/j.immuni.2020.04.014
A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma
Nature Medicine · 2019 · https://doi.org/10.1038/s41591-019-0357-y
TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion
Nature · 2019 · https://doi.org/10.1038/s41586-019-1325-x
TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision
Immunity · 2019 · https://doi.org/10.1016/j.immuni.2019.09.013
Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells
Immunity · 2018 · https://doi.org/10.1016/j.immuni.2018.04.026
Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
Nature Medicine · 2018 · https://doi.org/10.1038/s41591-018-0010-1
Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Nature · 2018 · https://doi.org/10.1038/s41586-018-0392-8
T-cell invigoration to tumour burden ratio associated with anti-PD-1 response
Nature · 2017 · https://doi.org/10.1038/nature22079
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
Science · 2016 · 10.1126/science.aaf2807
Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade
Cell · 2016 · 10.1016/j.cell.2016.11.022
Current projects
No projects listed.