Paul W.H.I. Parren

Research interests

Publications

• Avidity in antibody effector functions and biotherapeutic drug design

  Nature Reviews Drug Discovery · 2022 · 10.1038/s41573-022-00501-8

• Bispecific antibodies: a mechanistic review of the pipeline

  Nature Reviews Drug Discovery · 2019 · https://doi.org/10.1038/s41573-019-0028-1

• Monoclonal antibodies targeting CD 38 in hematological malignancies and beyond

  Immunological Reviews · 2016 · 10.1111/imr.12389

• A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

  PLoS Biology · 2016 · https://doi.org/10.1371/journal.pbio.1002344

• A Novel Bispecific Antibody Targeting EGFR and cMet Is Effective against EGFR Inhibitor–Resistant Lung Tumors

  Cancer Research · 2016 · 10.1158/0008-5472.can-15-2833

• The Therapeutic CD38 Monoclonal Antibody Daratumumab Induces Programmed Cell Death via Fcγ Receptor–Mediated Cross-Linking

  The Journal of Immunology · 2016 · 10.4049/jimmunol.1501351

• Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma

  mAbs · 2015 · 10.1080/19420862.2015.1007813

• Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

  Science · 2014 · https://doi.org/10.1126/science.1248943

• Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange

  Proceedings of the National Academy of Sciences · 2013 · 10.1073/pnas.1220145110

• Daratumumab, a Novel Therapeutic Human CD38 Monoclonal Antibody, Induces Killing of Multiple Myeloma and Other Hematological Tumors

  The Journal of Immunology · 2010 · https://doi.org/10.4049/jimmunol.1003032

• Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques

  Nature Medicine · 2009 · 10.1038/nm.1974

• Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

  Nature Biotechnology · 2009 · 10.1038/nbt.1553

• Binding of Submaximal C1q Promotes Complement-Dependent Cytotoxicity (CDC) of B Cells Opsonized with Anti-CD20 mAbs Ofatumumab (OFA) or Rituximab (RTX): Considerably Higher Levels of CDC Are Induced by OFA than by RTX

  The Journal of Immunology · 2009 · 10.4049/jimmunol.0900632

• Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange

  Science · 2007 · https://doi.org/10.1126/science.1144603

• Fc receptor but not complement binding is important in antibody protection against HIV

  Nature · 2007 · https://doi.org/10.1038/nature06106

• The Biological Activity of Human CD20 Monoclonal Antibodies Is Linked to Unique Epitopes on CD20

  The Journal of Immunology · 2006 · 10.4049/jimmunol.177.1.362

• Targeting interleukin‐15 in patients with rheumatoid arthritis: A proof‐of‐concept study

  Arthritis & Rheumatism · 2005 · 10.1002/art.21249

• HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites

  Nature · 2002 · 10.1038/nature01188

• Effector Function Activities of a Panel of Mutants of a Broadly Neutralizing Antibody against Human Immunodeficiency Virus Type 1

  Journal of Virology · 2001 · 10.1128/jvi.75.24.12161-12168.2001

• Crystal Structure of a Neutralizing Human IgG Against HIV-1: A Template for Vaccine Design

  Science · 2001 · 10.1126/science.1061692

• Antibody Protects Macaques against Vaginal Challenge with a Pathogenic R5 Simian/Human Immunodeficiency Virus at Serum Levels Giving Complete Neutralization In Vitro

  Journal of Virology · 2001 · 10.1128/jvi.75.17.8340-8347.2001

• Broadly Neutralizing Antibodies Targeted to the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 Glycoprotein gp41

  Journal of Virology · 2001 · 10.1128/jvi.75.22.10892-10905.2001

• Ebola Virus Can Be Effectively Neutralized by Antibody Produced in Natural Human Infection

  Journal of Virology · 1999 · 10.1128/jvi.73.7.6024-6030.1999

• Efficient Neutralization of Primary Isolates of HIV-1 by a Recombinant Human Monoclonal Antibody

  Science · 1994 · 10.1126/science.7973652

• On the interaction of IgG subclasses with the low affinity Fc gamma RIIa (CD32) on human monocytes, neutrophils, and platelets. Analysis of a functional polymorphism to human IgG2.

  Journal of Clinical Investigation · 1992 · 10.1172/jci116022

• The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

  Cell · 1987 · 10.1016/0092-8674(87)90038-9

Current projects

No projects listed.