Christine L. Mummery

Research interests

Publications

• Organs-on-chips: into the next decade

  Nature Reviews Drug Discovery · 2020 · https://doi.org/10.1038/s41573-020-0079-3

• Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease

  Cell stem cell · 2020 · https://doi.org/10.1016/j.stem.2020.05.004

• MUSCLEMOTION

  Circulation Research · 2017 · https://doi.org/10.1161/circresaha.117.312067

• Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure

  European Heart Journal · 2016 · https://doi.org/10.1093/eurheartj/ehw113

• Small molecule absorption by PDMS in the context of drug response bioassays

  Biochemical and Biophysical Research Communications · 2016 · https://doi.org/10.1016/j.bbrc.2016.11.062

• Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology

  EMBO Molecular Medicine · 2015 · https://doi.org/10.15252/emmm.201404757

• Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

  Science · 2015 · https://doi.org/10.1126/science.1259418

• Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells

  Nature Protocols · 2014 · https://doi.org/10.1038/nprot.2014.102

• Induced pluripotent stem cells: the new patient?

  Nature Reviews Molecular Cell Biology · 2012 · https://doi.org/10.1038/nrm3448

• Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells to Cardiomyocytes

  Circulation Research · 2012 · https://doi.org/10.1161/circresaha.110.227512

• Cardiomyocytes Derived From Pluripotent Stem Cells Recapitulate Electrophysiological Characteristics of an Overlap Syndrome of Cardiac Sodium Channel Disease

  Circulation · 2012 · https://doi.org/10.1161/circulationaha.111.066092

• NKX2-5eGFP/w hESCs for isolation of human cardiac progenitors and cardiomyocytes

  Nature Methods · 2011 · https://doi.org/10.1038/nmeth.1740

• Phosphorylation Dynamics during Early Differentiation of Human Embryonic Stem Cells

  Cell stem cell · 2009 · https://doi.org/10.1016/j.stem.2009.05.021

• Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes

  Stem Cell Research · 2009 · https://doi.org/10.1016/j.scr.2009.11.004

• Recombinant Vitronectin Is a Functionally Defined Substrate That Supports Human Embryonic Stem Cell Self-Renewal via αVβ5 Integrin

  Stem Cells · 2008 · https://doi.org/10.1634/stemcells.2008-0291

• Stem-cell-based therapy and lessons from the heart

  Nature · 2008 · https://doi.org/10.1038/nature07040

• Human embryonic stem cell-derived cardiomyocytes survive and mature in the mouse heart and transiently improve function after myocardial infarction

  Stem Cell Research · 2007 · https://doi.org/10.1016/j.scr.2007.06.001

• MicroRNAs in the Human Heart

  Circulation · 2007 · https://doi.org/10.1161/circulationaha.107.687947

• Autotaxin, a Secreted Lysophospholipase D, Is Essential for Blood Vessel Formation during Development

  Molecular and Cellular Biology · 2006 · https://doi.org/10.1128/mcb.02419-05

• Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin

  Journal of Cell Science · 2004 · https://doi.org/10.1242/jcs.00970

• Endoglin promotes endothelial cell proliferation and TGF‐β/ALK1 signal transduction

  The EMBO Journal · 2004 · https://doi.org/10.1038/sj.emboj.7600386

• Activin Receptor-like Kinase (ALK)1 Is an Antagonistic Mediator of Lateral TGFβ/ALK5 Signaling

  Molecular Cell · 2003 · https://doi.org/10.1016/s1097-2765(03)00386-1

• Differentiation of Human Embryonic Stem Cells to Cardiomyocytes

  Circulation · 2003 · https://doi.org/10.1161/01.cir.0000068356.38592.68

• Abnormal angiogenesis but intact hematopoietic potential in TGF‐β type I receptor‐deficient mice

  The EMBO Journal · 2001 · https://doi.org/10.1093/emboj/20.7.1663

• Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice

  The International Journal of Developmental Biology · 2000 · https://doi.org/10.1387/ijdb.10853822

Current projects

No projects listed.