Jiří Bártek

Research interests

Publications

• Apoptotic cell death in disease—Current understanding of the NCCD 2023

  Cell Death and Differentiation · 2023 · https://doi.org/10.1038/s41418-023-01153-w

• A Deep Learning Framework for Predicting Response to Therapy in Cancer

  Cell Reports · 2019 · https://doi.org/10.1016/j.celrep.2019.11.017

• Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

  Nature · 2017 · https://doi.org/10.1038/nature25016

• Replication stress links structural and numerical cancer chromosomal instability

  Nature · 2013 · https://doi.org/10.1038/nature11935

• The causes and consequences of genetic heterogeneity in cancer evolution

  Nature · 2013 · https://doi.org/10.1038/nature12625

• TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

  Cell · 2012 · https://doi.org/10.1016/j.cell.2012.06.039

• 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

  Nature Cell Biology · 2011 · https://doi.org/10.1038/ncb2201

• 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

  Nature Structural & Molecular Biology · 2010 · https://doi.org/10.1038/nsmb.1831

• The DNA-damage response in human biology and disease

  Nature · 2009 · https://doi.org/10.1038/nature08467

• An Oncogene-Induced DNA Damage Model for Cancer Development

  Science · 2008 · https://doi.org/10.1126/science.1140735

• Human CtIP promotes DNA end resection

  Nature · 2007 · https://doi.org/10.1038/nature06337

• RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins

  Cell · 2007 · https://doi.org/10.1016/j.cell.2007.09.040

• Deregulated Overexpression of hCdt1 and hCdc6 Promotes Malignant Behavior

  Cancer Research · 2007 · https://doi.org/10.1158/0008-5472.can-07-2837

• Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

  Nature Cell Biology · 2006 · https://doi.org/10.1038/ncb1446

• Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

  Nature · 2006 · https://doi.org/10.1038/nature05268

• DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

  Nature · 2005 · https://doi.org/10.1038/nature03482

• Cell-cycle checkpoints and cancer

  Nature · 2004 · https://doi.org/10.1038/nature03097

• Chk1 and Chk2 kinases in checkpoint control and cancer

  Cancer Cell · 2003 · https://doi.org/10.1016/s1535-6108(03)00110-7

• The ATM–Chk2–Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

  Nature · 2001 · https://doi.org/10.1038/35071124

Current projects

No projects listed.