Nobutaka Hattori

Research interests

Publications

• Propagative α-synuclein seeds as serum biomarkers for synucleinopathies

  Nature Medicine · 2023 · 10.1038/s41591-023-02358-9

• Levodopa Dose Equivalency in Parkinson's Disease: Updated Systematic Review and Proposals

  Movement Disorders · 2023 · 10.1002/mds.29410

• CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study

  The Lancet Neurology · 2015 · 10.1016/s1474-4422(14)70266-2

• PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

  Scientific Reports · 2012 · 10.1038/srep01002

• Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

  Molecular Brain · 2012 · 10.1186/1756-6606-5-35

• PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

  Nature Communications · 2012 · https://doi.org/10.1038/ncomms2016

• Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria

  PLoS Genetics · 2012 · 10.1371/journal.pgen.1002537

• Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition

  Autophagy · 2011 · 10.4161/auto.7.2.14074

• Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case–control study

  The Lancet Neurology · 2011 · 10.1016/s1474-4422(11)70175-2

• A rotarod test for evaluation of motor skill learning

  Journal of Neuroscience Methods · 2010 · 10.1016/j.jneumeth.2010.03.026

• PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

  The Journal of Cell Biology · 2010 · https://doi.org/10.1083/jcb.200910140

• p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria

  Genes to Cells · 2010 · 10.1111/j.1365-2443.2010.01426.x

• Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

  Nature Genetics · 2009 · https://doi.org/10.1038/ng.485

• LRRK2 regulates synaptic vesicle endocytosis

  Experimental Cell Research · 2008 · 10.1016/j.yexcr.2008.02.015

• Genomic investigation of α‐synuclein multiplication and parkinsonism

  Annals of Neurology · 2008 · 10.1002/ana.21380

• Mitochondrial Genome Variation in Eastern Asia and the Peopling of Japan

  Genome Research · 2004 · 10.1101/gr.2286304

• Parkin Localizes to the Lewy Bodies of Parkinson Disease and Dementia with Lewy Bodies

  American Journal Of Pathology · 2002 · 10.1016/s0002-9440(10)61113-3

• Ubiquitination of a New Form of α-Synuclein by Parkin from Human Brain: Implications for Parkinson's Disease

  Science · 2001 · https://doi.org/10.1126/science.1060627

• An Unfolded Putative Transmembrane Polypeptide, which Can Lead to Endoplasmic Reticulum Stress, Is a Substrate of Parkin

  Cell · 2001 · 10.1016/s0092-8674(01)00407-x

• Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

  Nature Genetics · 2000 · https://doi.org/10.1038/77060

• Methylglyoxal Modification of Protein

  Journal of Biological Chemistry · 1999 · 10.1074/jbc.274.26.18492

• Mitochondrial Electron Transport Complex I Is a Potential Source of Oxygen Free Radicals in the Failing Myocardium

  Circulation Research · 1999 · 10.1161/01.res.85.4.357

• Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

  Nature · 1998 · https://doi.org/10.1038/33416

• Protein-bound acrolein: Potential markers for oxidative stress

  Proceedings of the National Academy of Sciences · 1998 · 10.1073/pnas.95.9.4882

• Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.

  Proceedings of the National Academy of Sciences · 1996 · 10.1073/pnas.93.7.2696

Current projects

No projects listed.