Jörg Kleeff

Research interests

Publications

• Therapeutic developments in pancreatic cancer: current and future perspectives

  Nature Reviews Gastroenterology & Hepatology · 2018 · https://doi.org/10.1038/s41575-018-0005-x

• Inter‐ and intra‐tumoural heterogeneity in cancer‐associated fibroblasts of human pancreatic ductal adenocarcinoma

  The Journal of Pathology · 2018 · 10.1002/path.5224

• Chronic pancreatitis

  Nature Reviews Disease Primers · 2017 · https://doi.org/10.1038/nrdp.2017.60

• The Impact of Positive Resection Margins on Survival and Recurrence Following Resection and Adjuvant Chemotherapy for Pancreatic Ductal Adenocarcinoma

  Annals of Surgery · 2017 · 10.1097/sla.0000000000002557

• Pancreatic cancer

  Nature Reviews Disease Primers · 2016 · https://doi.org/10.1038/nrdp.2016.22

• Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer

  Molecular Cancer · 2015 · 10.1186/s12943-015-0358-5

• Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma

  Nature Medicine · 2015 · https://doi.org/10.1038/nm.3952

• Pancreatogastrostomy Versus Pancreatojejunostomy for RECOnstruction After PANCreatoduodenectomy (RECOPANC, DRKS 00000767)

  Annals of Surgery · 2015 · 10.1097/sla.0000000000001240

• Addressing the challenges of pancreatic cancer: Future directions for improving outcomes

  Pancreatology · 2014 · 10.1016/j.pan.2014.10.001

• The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

  Nature Reviews Gastroenterology & Hepatology · 2012 · https://doi.org/10.1038/nrgastro.2012.115

• StellaTUM: current consensus and discussion on pancreatic stellate cell research

  Gut · 2011 · https://doi.org/10.1136/gutjnl-2011-301220

• Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trial

  The Lancet · 2011 · 10.1016/s0140-6736(11)60237-7

• Preoperative/Neoadjuvant Therapy in Pancreatic Cancer: A Systematic Review and Meta-analysis of Response and Resection Percentages

  PLoS Medicine · 2010 · https://doi.org/10.1371/journal.pmed.1000267

• Cancer-Stellate Cell Interactions Perpetuate the Hypoxia-Fibrosis Cycle in Pancreatic Ductal Adenocarcinoma

  Neoplasia · 2009 · 10.1593/neo.81618

• The Activated Stroma Index Is a Novel and Independent Prognostic Marker in Pancreatic Ductal Adenocarcinoma

  Clinical Gastroenterology and Hepatology · 2008 · 10.1016/j.cgh.2008.05.006

• Systematic Review and Meta-Analysis of the Role of Defunctioning Stoma in Low Rectal Cancer Surgery

  Annals of Surgery · 2008 · https://doi.org/10.1097/sla.0b013e318176bf65

• Most Pancreatic Cancer Resections are R1 Resections

  Annals of Surgical Oncology · 2008 · 10.1245/s10434-008-9839-8

• Surgery for Recurrent Pancreatic Ductal Adenocarcinoma

  Annals of Surgery · 2007 · https://doi.org/10.1097/01.sla.0000245845.06772.7d

• Distal Pancreatectomy

  Annals of Surgery · 2007 · 10.1097/01.sla.0000251438.43135.fb

• Systematic review and meta-analysis of standard and extended lymphadenectomy in pancreaticoduodenectomy for pancreatic cancer

  British journal of surgery · 2007 · 10.1002/bjs.5716

• Periostin Creates a Tumor-Supportive Microenvironment in the Pancreas by Sustaining Fibrogenic Stellate Cell Activity

  Gastroenterology · 2007 · 10.1053/j.gastro.2007.01.031

• Is There Still a Role for Total Pancreatectomy?

  Annals of Surgery · 2007 · 10.1097/sla.0b013e31815c2ca3

• Transcriptional network governing the angiogenic switch in human pancreatic cancer

  Proceedings of the National Academy of Sciences · 2007 · https://doi.org/10.1073/pnas.0705505104

• Enhanced glypican-3 expression differentiates the majority of hepatocellular carcinomas from benign hepatic disorders

  Gut · 2001 · 10.1136/gut.48.4.558

• Glypican-1 is overexpressed in human breast cancer and modulates the mitogenic effects of multiple heparin-binding growth factors in breast cancer cells.

  PubMed · 2001

• The TGF-β signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer

  Oncogene · 1999 · 10.1038/sj.onc.1202909

• The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer.

  Journal of Clinical Investigation · 1998 · 10.1172/jci4105

Current projects

No projects listed.