Henrik Zetterberg

Research interests

Publications

• Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease Pathology

  JAMA Neurology · 2024 · https://doi.org/10.1001/jamaneurol.2023.5319

• Biomarker-based staging of Alzheimer disease: rationale and clinical applications

  Nature Reviews Neurology · 2024 · https://doi.org/10.1038/s41582-024-00942-2

• Neuroinflammation in Alzheimer disease

  Nature reviews. Immunology · 2024 · https://doi.org/10.1038/s41577-024-01104-7

• Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease

  Nature Medicine · 2023 · https://doi.org/10.1038/s41591-023-02380-x

• Hallmarks of neurodegenerative diseases

  Cell · 2023 · https://doi.org/10.1016/j.cell.2022.12.032

• Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's disease

  EBioMedicine · 2022 · https://doi.org/10.1016/j.ebiom.2022.103836

• Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer’s disease

  Brain · 2022 · https://doi.org/10.1093/brain/awac333

• Association of Phosphorylated Tau Biomarkers With Amyloid Positron Emission Tomography vs Tau Positron Emission Tomography

  JAMA Neurology · 2022 · https://doi.org/10.1001/jamaneurol.2022.4485

• Biomarker modeling of Alzheimer’s disease using PET-based Braak staging

  Nature Aging · 2022 · https://doi.org/10.1038/s43587-022-00204-0

• Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical utility

  Nature Reviews Neurology · 2022 · https://doi.org/10.1038/s41582-022-00665-2

• Plasma p-tau231: a new biomarker for incipient Alzheimer’s disease pathology

  Acta Neuropathologica · 2021 · https://doi.org/10.1007/s00401-021-02275-6

• Head-to-Head Comparison of 8 Plasma Amyloid-β 42/40 Assays in Alzheimer Disease

  JAMA Neurology · 2021 · https://doi.org/10.1001/jamaneurol.2021.3180

• Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease Continuum

  JAMA Neurology · 2021 · https://doi.org/10.1001/jamaneurol.2021.3671

• The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's disease

  Alzheimer s & Dementia · 2021 · https://doi.org/10.1002/alz.12283

• Microglial activation and tau propagate jointly across Braak stages

  Nature Medicine · 2021 · https://doi.org/10.1038/s41591-021-01456-w

• A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease

  Nature Genetics · 2021 · 10.1038/s41588-021-00921-z

• A multicentre validation study of the diagnostic value of plasma neurofilament light

  Nature Communications · 2021 · https://doi.org/10.1038/s41467-021-23620-z

• Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia

  Journal of Neurology Neurosurgery & Psychiatry · 2020 · https://doi.org/10.1136/jnnp-2019-321954

• Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer’s Disease Neuroimaging Initiative

  Molecular Psychiatry · 2020 · https://doi.org/10.1038/s41380-020-00923-z

• Diagnostic value of plasma phosphorylated tau181 in Alzheimer’s disease and frontotemporal lobar degeneration

  Nature Medicine · 2020 · https://doi.org/10.1038/s41591-020-0762-2

• Plasma P-tau181 in Alzheimer’s disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer’s dementia

  Nature Medicine · 2020 · 10.1038/s41591-020-0755-1

• Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders

  JAMA · 2020 · 10.1001/jama.2020.12134

• Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts

  The Lancet Neurology · 2020 · 10.1016/s1474-4422(20)30071-5

• Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology

  JAMA Neurology · 2019 · https://doi.org/10.1001/jamaneurol.2019.1534

• Neurofilament light chain as a biomarker in neurological disorders

  Journal of Neurology Neurosurgery & Psychiatry · 2019 · 10.1136/jnnp-2018-320106

• Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study

  Alzheimer s & Dementia · 2019 · https://doi.org/10.1016/j.jalz.2019.01.015

• Neurofilaments as biomarkers in neurological disorders

  Nature Reviews Neurology · 2018 · https://doi.org/10.1038/s41582-018-0058-z

• Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic

  Nature Reviews Neurology · 2018 · 10.1038/s41582-018-0079-7

• Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis

  Annals of Neurology · 2017 · 10.1002/ana.24954

• Consensus guidelines for lumbar puncture in patients with neurological diseases

  Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · 2017 · https://doi.org/10.1016/j.dadm.2017.04.007

• Gut microbiome alterations in Alzheimer’s disease

  Scientific Reports · 2017 · https://doi.org/10.1038/s41598-017-13601-y

• Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study

  The Lancet Neurology · 2017 · https://doi.org/10.1016/s1474-4422(17)30400-3

• Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study

  Brain · 2016 · https://doi.org/10.1093/brain/aww160

• Defeating Alzheimer's disease and other dementias: a priority for European science and society

  The Lancet Neurology · 2016 · 10.1016/s1474-4422(16)00062-4

• CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

  The Lancet Neurology · 2016 · https://doi.org/10.1016/s1474-4422(16)00070-3

• Clearance systems in the brain—implications for Alzheimer disease

  Nature Reviews Neurology · 2015 · 10.1038/nrneurol.2015.119

• Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study

  Alzheimer s & Dementia · 2015 · https://doi.org/10.1016/j.jalz.2015.08.003

• Cerebrospinal fluid biomarkers in trials for Alzheimer and Parkinson diseases

  Nature Reviews Neurology · 2014 · https://doi.org/10.1038/nrneurol.2014.232

• Cerebrospinal fluid and plasma biomarkers in Alzheimer disease

  Nature Reviews Neurology · 2010 · https://doi.org/10.1038/nrneurol.2010.4

• Alzheimer's disease

  The Lancet · 2006 · https://doi.org/10.1016/s0140-6736(06)69113-7

• Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study

  The Lancet Neurology · 2006 · 10.1016/s1474-4422(06)70355-6

Current projects

No projects listed.