Timothy D. McHugh

Research interests

Publications

• Bedaquiline–Pretomanid–Linezolid Regimens for Drug-Resistant Tuberculosis

  New England Journal of Medicine · 2022 · 10.1056/nejmoa2119430

• A 24-Week, All-Oral Regimen for Rifampin-Resistant Tuberculosis

  New England Journal of Medicine · 2022 · 10.1056/nejmoa2117166

• Emergence of new SARS-CoV-2 Variant of Concern Omicron (B.1.1.529) - highlights Africa's research capabilities, but exposes major knowledge gaps, inequities of vaccine distribution, inadequacies in global COVID-19 response and control efforts

  International Journal of Infectious Diseases · 2021 · https://doi.org/10.1016/j.ijid.2021.11.040

• Global Tuberculosis Report 2020 – Reflections on the Global TB burden, treatment and prevention efforts

  International Journal of Infectious Diseases · 2021 · https://doi.org/10.1016/j.ijid.2021.02.107

• Is Africa prepared for tackling the COVID-19 (SARS-CoV-2) epidemic. Lessons from past outbreaks, ongoing pan-African public health efforts, and implications for the future

  International Journal of Infectious Diseases · 2020 · 10.1016/j.ijid.2020.02.049

• COVID-19—Zoonosis or Emerging Infectious Disease?

  Frontiers in Public Health · 2020 · https://doi.org/10.3389/fpubh.2020.596944

• The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health — The latest 2019 novel coronavirus outbreak in Wuhan, China

  International Journal of Infectious Diseases · 2020 · https://doi.org/10.1016/j.ijid.2020.01.009

• Treatment of Highly Drug-Resistant Pulmonary Tuberculosis

  New England Journal of Medicine · 2020 · https://doi.org/10.1056/nejmoa1901814

• Smartphone-enabled video-observed versus directly observed treatment for tuberculosis: a multicentre, analyst-blinded, randomised, controlled superiority trial

  The Lancet · 2019 · 10.1016/s0140-6736(18)32993-3

• Tuberculosis: advances and challenges in development of new diagnostics and biomarkers

  The Lancet Infectious Diseases · 2018 · 10.1016/s1473-3099(18)30111-7

• Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies

  The Lancet Infectious Diseases · 2018 · 10.1016/s1473-3099(18)30110-5

• Monkeypox — Enhancing public health preparedness for an emerging lethal human zoonotic epidemic threat in the wake of the smallpox post-eradication era

  International Journal of Infectious Diseases · 2018 · https://doi.org/10.1016/j.ijid.2018.11.008

• Direct Whole-Genome Sequencing of Sputum Accurately Identifies Drug-Resistant Mycobacterium tuberculosis Faster than MGIT Culture Sequencing

  Journal of Clinical Microbiology · 2018 · https://doi.org/10.1128/jcm.00666-18

• The transmission of Mycobacterium tuberculosis in high burden settings

  The Lancet Infectious Diseases · 2016 · https://doi.org/10.1016/s1473-3099(15)00499-5

• A Dose-Ranging Trial to Optimize the Dose of Rifampin in the Treatment of Tuberculosis

  American Journal of Respiratory and Critical Care Medicine · 2015 · 10.1164/rccm.201407-1264oc

• Rapid Whole-Genome Sequencing of Mycobacterium tuberculosis Isolates Directly from Clinical Samples

  Journal of Clinical Microbiology · 2015 · 10.1128/jcm.00486-15

• Four-Month Moxifloxacin-Based Regimens for Drug-Sensitive Tuberculosis

  New England Journal of Medicine · 2014 · 10.1056/nejmoa1407426

• High-Dose Rifapentine with Moxifloxacin for Pulmonary Tuberculosis

  New England Journal of Medicine · 2014 · 10.1056/nejmoa1314210

• New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects

  The Lancet Infectious Diseases · 2014 · 10.1016/s1473-3099(13)70328-1

• Drug-resistant tuberculosis: time for visionary political leadership

  The Lancet Infectious Diseases · 2013 · 10.1016/s1473-3099(13)70030-6

• Advances in tuberculosis diagnostics: the Xpert MTB/RIF assay and future prospects for a point-of-care test

  The Lancet Infectious Diseases · 2013 · 10.1016/s1473-3099(13)70008-2

• Whole-genome sequencing to establish relapse or re-infection with Mycobacterium tuberculosis: a retrospective observational study

  The Lancet Respiratory Medicine · 2013 · 10.1016/s2213-2600(13)70231-5

• Changes in prevalence and load of airway bacteria using quantitative PCR in stable and exacerbated COPD

  Thorax · 2012 · 10.1136/thoraxjnl-2012-201924

• Tuberculosis Diagnostics and Biomarkers: Needs, Challenges, Recent Advances, and Opportunities

  The Journal of Infectious Diseases · 2012 · https://doi.org/10.1093/infdis/jir860

• Drug-Resistant Tuberculosis—Current Dilemmas, Unanswered Questions, Challenges, and Priority Needs

  The Journal of Infectious Diseases · 2012 · https://doi.org/10.1093/infdis/jir858

• Physiological Cost of Rifampin Resistance Induced In Vitro in Mycobacterium tuberculosis

  Antimicrobial Agents and Chemotherapy · 1999 · 10.1128/aac.43.8.1866

Current projects

No projects listed.