Guy Brusselle

Research interests

Publications

• Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

  Nature Genetics · 2023 · https://doi.org/10.1038/s41588-023-01314-0

• Key recommendations for primary care from the 2022 Global Initiative for Asthma (GINA) update

  npj Primary Care Respiratory Medicine · 2023 · 10.1038/s41533-023-00330-1

• Global Initiative for Asthma Strategy 2021: executive summary and rationale for key changes

  European Respiratory Journal · 2021 · 10.1183/13993003.02730-2021

• Eosinophilic and Noneosinophilic Asthma

  CHEST Journal · 2021 · https://doi.org/10.1016/j.chest.2021.04.013

• Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence

  Journal of Allergy and Clinical Immunology · 2019 · 10.1016/j.jaci.2019.06.049

• Blood eosinophils and treatment response with triple and dual combination therapy in chronic obstructive pulmonary disease: analysis of the IMPACT trial

  The Lancet Respiratory Medicine · 2019 · https://doi.org/10.1016/s2213-2600(19)30190-0

• GINA 2019: a fundamental change in asthma management

  European Respiratory Journal · 2019 · 10.1183/13993003.01046-2019

• Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

  Nature Genetics · 2019 · 10.1038/s41588-018-0342-2

• Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine

  The Journal of Pathology · 2019 · https://doi.org/10.1002/path.5364

• Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma

  New England Journal of Medicine · 2018 · https://doi.org/10.1056/nejmoa1804093

• Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

  Nature Genetics · 2017 · 10.1038/s41588-017-0014-7

• After asthma: redefining airways diseases

  The Lancet · 2017 · https://doi.org/10.1016/s0140-6736(17)30879-6

• The Rotterdam Study: 2018 update on objectives, design and main results

  European Journal of Epidemiology · 2017 · 10.1007/s10654-017-0321-4

• Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

  Nature Genetics · 2017 · 10.1038/ng.3752

• Treatable traits: toward precision medicine of chronic airway diseases

  European Respiratory Journal · 2016 · https://doi.org/10.1183/13993003.01359-2015

• Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials

  The Lancet Respiratory Medicine · 2015 · https://doi.org/10.1016/s2213-2600(15)00042-9

• The Rotterdam Study: 2016 objectives and design update

  European Journal of Epidemiology · 2015 · 10.1007/s10654-015-0082-x

• Management of COPD in the UK primary-care setting: an analysis of real-life prescribing patterns

  International Journal of COPD · 2014 · https://doi.org/10.2147/copd.s62750

• Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

  New England Journal of Medicine · 2014 · https://doi.org/10.1056/nejmoa1403290

• Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial

  Thorax · 2013 · 10.1136/thoraxjnl-2012-202698

• Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma

  Journal of Allergy and Clinical Immunology · 2012 · 10.1016/j.jaci.2012.07.047

• Risk-to-benefit ratio of inhaled corticosteroids in patients with COPD

  Primary Care Respiratory Journal · 2012 · https://doi.org/10.4104/pcrj.2012.00092

• Properties of the COPD assessment test in a cross-sectional European study

  European Respiratory Journal · 2011 · 10.1183/09031936.00177210

• Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

  Nature Genetics · 2011 · 10.1038/ng.941

• New insights into the immunology of chronic obstructive pulmonary disease

  The Lancet · 2011 · 10.1016/s0140-6736(11)60988-4

• Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

  Nature Genetics · 2009 · 10.1038/ng.500

• Lymphoid follicles in (very) severe COPD: beneficial or harmful?

  European Respiratory Journal · 2009 · https://doi.org/10.1183/09031936.00150208

• Effectiveness of pharmacist intervention for asthma control improvement

  European Respiratory Journal · 2007 · https://doi.org/10.1183/09031936.00112007

• Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema

  Respiratory Research · 2006 · 10.1186/1465-9921-7-53

• Time course of cigarette smoke-induced pulmonary inflammation in mice

  European Respiratory Journal · 2005 · 10.1183/09031936.05.00095204

• Interleukin-12 Inhibits Antigen-Induced Airway Hyperresponsiveness in Mice

  American Journal of Respiratory and Critical Care Medicine · 1996 · https://doi.org/10.1164/ajrccm.153.2.8564093

• Allergen-Induced Airway Inflammation and Bronchial Responsiveness in Wild-Type and Interleukin-4-Deficient Mice

  American Journal of Respiratory Cell and Molecular Biology · 1995 · https://doi.org/10.1165/ajrcmb.12.3.7873190

• Attenuation of allergic airway inflammation in IL‐4 deficient mice

  Clinical & Experimental Allergy · 1994 · 10.1111/j.1365-2222.1994.tb00920.x

Current projects

No projects listed.