Cynthia Hawkins

Research interests

Publications

• The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

  Neuro-Oncology · 2021 · https://doi.org/10.1093/neuonc/noab106

• DNA hypermethylation within TERT promoter upregulates TERT expression in cancer

  Journal of Clinical Investigation · 2018 · https://doi.org/10.1172/jci121303

• Intertumoral Heterogeneity within Medulloblastoma Subgroups

  Cancer Cell · 2017 · https://doi.org/10.1016/j.ccell.2017.05.005

• Comprehensive Analysis of Hypermutation in Human Cancer

  Cell · 2017 · https://doi.org/10.1016/j.cell.2017.09.048

• Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas

  Journal of Clinical Oncology · 2017 · https://doi.org/10.1200/jco.2016.71.8726

• Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma

  Cancer Cell · 2017 · https://doi.org/10.1016/j.ccell.2017.08.017

• Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency

  Journal of Clinical Oncology · 2016 · https://doi.org/10.1200/jco.2016.66.6552

• Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

  The Lancet Oncology · 2016 · https://doi.org/10.1016/s1470-2045(15)00581-1

• Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

  Nature Genetics · 2015 · https://doi.org/10.1038/ng.3202

• Study of the biodistribution of fluorescein in glioma-infiltrated mouse brain and histopathological correlation of intraoperative findings in high-grade gliomas resected under fluorescein fluorescence guidance

  Journal of neurosurgery · 2015 · https://doi.org/10.3171/2015.2.jns132507

• Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

  Nature Genetics · 2014 · https://doi.org/10.1038/ng.2936

• Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

  Nature · 2014 · https://doi.org/10.1038/nature13108

• Cytogenetic Prognostication Within Medulloblastoma Subgroups

  Journal of Clinical Oncology · 2014 · https://doi.org/10.1200/jco.2013.50.9539

• Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study

  The Lancet Oncology · 2013 · https://doi.org/10.1016/s1470-2045(13)70110-4

• Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis

  The Lancet Oncology · 2013 · https://doi.org/10.1016/s1470-2045(13)70449-2

• Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

  Cell · 2012 · 10.1016/j.cell.2011.12.013

• Glioblastoma, a Brief Review of History, Molecular Genetics, Animal Models and Novel Therapeutic Strategies

  Archivum Immunologiae et Therapiae Experimentalis · 2012 · https://doi.org/10.1007/s00005-012-0203-0

• K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

  Acta Neuropathologica · 2012 · 10.1007/s00401-012-0998-0

• Medulloblastoma Comprises Four Distinct Molecular Variants

  Journal of Clinical Oncology · 2010 · https://doi.org/10.1200/jco.2009.27.4324

• Identification of human brain tumour initiating cells

  Nature · 2004 · https://doi.org/10.1038/nature03128

• Identification of a cancer stem cell in human brain tumors.

  PubMed · 2003

Current projects

No projects listed.