Tiago F. Outeiro

Research interests

Publications

• A biological classification of Parkinson's disease: the SynNeurGe research diagnostic criteria

  The Lancet Neurology · 2024 · 10.1016/s1474-4422(23)00404-0

• α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity

  Proceedings of the National Academy of Sciences · 2022 · 10.1073/pnas.2109617119

• Dementia with Lewy bodies: an update and outlook

  Molecular Neurodegeneration · 2019 · 10.1186/s13024-019-0306-8

• Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons

  Proceedings of the National Academy of Sciences · 2018 · 10.1073/pnas.1804198115

• Glyoxal as an alternative fixative to formaldehyde in immunostaining and super‐resolution microscopy

  The EMBO Journal · 2017 · 10.15252/embj.201695709

• α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B

  Nature Neuroscience · 2017 · 10.1038/nn.4648

• The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

  PLoS Biology · 2017 · 10.1371/journal.pbio.2000374

• Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies

  Brain · 2017 · 10.1093/brain/awx056

• Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism

  Trends in Pharmacological Sciences · 2015 · 10.1016/j.tips.2015.08.001

• Structure, function and toxicity of alpha‐synuclein: the Bermuda triangle in synucleinopathies

  Journal of Neurochemistry · 2015 · 10.1111/jnc.13249

• Protein phosphorylation in neurodegeneration: friend or foe?

  Frontiers in Molecular Neuroscience · 2014 · 10.3389/fnmol.2014.00042

• Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment

  Autophagy · 2014 · 10.4161/auto.36436

• Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation

  PLoS Genetics · 2014 · 10.1371/journal.pgen.1004741

• SIRT1 and SIRT2: emerging targets in neurodegeneration

  EMBO Molecular Medicine · 2013 · 10.1002/emmm.201302451

• Alpha-synuclein: from secretion to dysfunction and death

  Cell Death and Disease · 2012 · 10.1038/cddis.2012.94

• Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

  Journal of Neuroscience · 2012 · 10.1523/jneurosci.0234-12.2012

• α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

  Journal of Clinical Investigation · 2011 · https://doi.org/10.1172/jci43366

• Convergence of miRNA Expression Profiling, α-Synuclein Interacton and GWAS in Parkinson's Disease

  PLoS ONE · 2011 · 10.1371/journal.pone.0025443

• Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

  PLoS ONE · 2008 · 10.1371/journal.pone.0001867

• Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration

  Experimental Neurology · 2008 · 10.1016/j.expneurol.2008.06.004

• Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease

  Science · 2007 · https://doi.org/10.1126/science.1143780

• Pharmacological promotion of inclusion formation: A therapeutic approach for Huntington’s and Parkinson’s diseases

  Proceedings of the National Academy of Sciences · 2006 · 10.1073/pnas.0511256103

• Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [ PSI + ] prion in yeast and aggregation of Sup35 in vitro

  Proceedings of the National Academy of Sciences · 2004 · 10.1073/pnas.0404968101

• Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or α-Synuclein

  Science · 2003 · 10.1126/science.1090389

• Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology

  Science · 2003 · https://doi.org/10.1126/science.1090439

Current projects

No projects listed.