Murray D. Norris

Research interests

Publications

• Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer

  Nature Medicine · 2020 · 10.1038/s41591-020-1072-4

• Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma

  Science Translational Medicine · 2019 · https://doi.org/10.1126/scitranslmed.aau1099

• A Myc Activity Signature Predicts Poor Clinical Outcomes in Myc-Associated Cancers

  Cancer Research · 2016 · 10.1158/0008-5472.can-15-2906

• ABC transporters as mediators of drug resistance and contributors to cancer cell biology

  Drug Resistance Updates · 2016 · 10.1016/j.drup.2016.03.001

• Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma

  Science Translational Medicine · 2015 · https://doi.org/10.1126/scitranslmed.aab1803

• ABCA Transporter Gene Expression and Poor Outcome in Epithelial Ovarian Cancer

  JNCI Journal of the National Cancer Institute · 2014 · 10.1093/jnci/dju149

• β-blockers increase response to chemotherapy via direct antitumour and anti-angiogenic mechanisms in neuroblastoma

  British Journal of Cancer · 2013 · https://doi.org/10.1038/bjc.2013.205

• The histone deacetylase SIRT2 stabilizes Myc oncoproteins

  Cell Death and Differentiation · 2012 · https://doi.org/10.1038/cdd.2012.147

• SIRT1 Promotes N-Myc Oncogenesis through a Positive Feedback Loop Involving the Effects of MKP3 and ERK on N-Myc Protein Stability

  PLoS Genetics · 2011 · https://doi.org/10.1371/journal.pgen.1002135

• ABC transporters in cancer: more than just drug efflux pumps

  Nature reviews. Cancer · 2010 · https://doi.org/10.1038/nrc2789

• miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma

  Nature Medicine · 2010 · https://doi.org/10.1038/nm.2227

• ODC1 Is a Critical Determinant of MYCN Oncogenesis and a Therapeutic Target in Neuroblastoma

  Cancer Research · 2008 · 10.1158/0008-5472.can-07-6866

• Role of the MRP1/ABCC1 Multidrug Transporter Protein in Cancer

  IUBMB Life · 2007 · 10.1080/15216540701736285

• Association of High-Level MRP1 Expression With Poor Clinical Outcome in a Large Prospective Study of Primary Neuroblastoma

  Journal of Clinical Oncology · 2006 · https://doi.org/10.1200/jco.2005.01.6196

• Expression of multidrug transporterMRP4/ABCC4is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecanin vitro

  Molecular Cancer Therapeutics · 2005 · 10.1158/1535-7163.mct-04-0161

• Mechanisms of embryonal tumor initiation: Distinct roles for MycN expression and MYCN amplification

  Proceedings of the National Academy of Sciences · 2004 · https://doi.org/10.1073/pnas.0401083101

• Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies

  Blood · 2004 · 10.1182/blood-2003-08-2911

• The p53 pathway and its inactivation in neuroblastoma

  Cancer Letters · 2003 · https://doi.org/10.1016/s0304-3835(03)00088-0

• The nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse model of childhood acute lymphoblastic leukemia reveals intrinsic differences in biologic characteristics at diagnosis and relapse

  Blood · 2002 · https://doi.org/10.1182/blood.v99.11.4100

• Multiple microtubule alterations are associated with Vinca alkaloid resistance in human leukemia cells.

  PubMed · 2001

• Prognostic significance of MYCN oncogene expression in childhood neuroblastoma.

  Journal of Clinical Oncology · 1998 · https://doi.org/10.1200/jco.1998.16.10.3286

• Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes.

  Journal of Clinical Investigation · 1997 · https://doi.org/10.1172/jci119642

• Expression of the Gene for Multidrug-Resistance–Associated Protein and Outcome in Patients with Neuroblastoma

  New England Journal of Medicine · 1996 · 10.1056/nejm199601253340405

• Altered Expression of Mβ2, the Class II β-Tubulin Isotype, in a Murine J774.2 Cell Line with a High Level of Taxol Resistance

  Journal of Biological Chemistry · 1995 · https://doi.org/10.1074/jbc.270.52.31269

• Expression of the multidrug resistance-associated protein (MRP) gene correlates with amplification and overexpression of the N-myc oncogene in childhood neuroblastoma.

  PubMed · 1994

Current projects

No projects listed.