Jaime Rodriguez‐Canales

Research interests

Publications

• Adavosertib plus gemcitabine for platinum-resistant or platinum-refractory recurrent ovarian cancer: a double-blind, randomised, placebo-controlled, phase 2 trial

  The Lancet · 2021 · 10.1016/s0140-6736(20)32554-x

• The Society for Immunotherapy of Cancer statement on best practices for multiplex immunohistochemistry (IHC) and immunofluorescence (IF) staining and validation

  Journal for ImmunoTherapy of Cancer · 2020 · 10.1136/jitc-2019-000155

• CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade

  Cancer Discovery · 2018 · 10.1158/2159-8290.cd-17-1033

• STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS -Mutant Lung Adenocarcinoma

  Cancer Discovery · 2018 · https://doi.org/10.1158/2159-8290.cd-18-0099

• Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma

  Journal of Clinical Oncology · 2018 · https://doi.org/10.1200/jco.2017.75.8219

• Validation of multiplex immunofluorescence panels using multispectral microscopy for immune-profiling of formalin-fixed and paraffin-embedded human tumor tissues

  Scientific Reports · 2017 · 10.1038/s41598-017-13942-8

• TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: An Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence

  Cancer Discovery · 2017 · 10.1158/2159-8290.cd-17-0256

• CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

  Nature · 2017 · 10.1038/nature22359

• Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial

  The Lancet Oncology · 2017 · https://doi.org/10.1016/s1470-2045(17)30624-1

• An Expression Signature as an Aid to the Histologic Classification of Non–Small Cell Lung Cancer

  Clinical Cancer Research · 2016 · 10.1158/1078-0432.ccr-15-2900

• Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis

  Cell Reports · 2016 · 10.1016/j.celrep.2016.07.009

• Diagnosis and Molecular Classification of Lung Cancer

  Cancer treatment and research · 2016 · 10.1007/978-3-319-40389-2_2

• Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome

  Proceedings of the National Academy of Sciences · 2016 · 10.1073/pnas.1521812113

• XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer

  Nature · 2016 · 10.1038/nature19771

• Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up

  Annals of Oncology · 2016 · 10.1093/annonc/mdw436

• Comprehensive Computational Pathological Image Analysis Predicts Lung Cancer Prognosis

  Journal of Thoracic Oncology · 2016 · 10.1016/j.jtho.2016.10.017

• A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition

  Clinical Cancer Research · 2015 · 10.1158/1078-0432.ccr-15-0876

• Molecular Portraits of Epithelial, Mesenchymal, and Hybrid States in Lung Adenocarcinoma and Their Relevance to Survival

  Cancer Research · 2015 · 10.1158/0008-5472.can-14-2535

• Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma

  Journal of Clinical Investigation · 2015 · 10.1172/jci74725

• Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma

  Molecular Cancer Research · 2015 · 10.1158/1541-7786.mcr-15-0307

• A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors

  Nature Genetics · 2014 · 10.1038/ng.3016

• Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

  Nature Immunology · 2011 · 10.1038/ni.1995

• Clonally related histiocytic/dendritic cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a study of seven cases

  Modern Pathology · 2011 · 10.1038/modpathol.2011.102

• Typical and Atypical Pulmonary Carcinoid Tumor Overdiagnosed as Small-Cell Carcinoma on Biopsy Specimens

  The American Journal of Surgical Pathology · 2005 · 10.1097/01.pas.0000149690.75462.29

• Gene Expression Profiles in Paraffin-Embedded Core Biopsy Tissue Predict Response to Chemotherapy in Women With Locally Advanced Breast Cancer

  Journal of Clinical Oncology · 2005 · 10.1200/jco.2005.02.0818

Current projects

No projects listed.