Yoshihiro Hayakawa

Research interests

Publications

• The Dark Side of IFN-γ: Its Role in Promoting Cancer Immunoevasion

  International Journal of Molecular Sciences · 2017 · 10.3390/ijms19010089

• The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING

  Cell Reports · 2013 · 10.1016/j.celrep.2013.05.009

• STING is a direct innate immune sensor of cyclic di-GMP

  Nature · 2011 · https://doi.org/10.1038/nature10429

• TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

  Infection and Immunity · 2010 · 10.1128/iai.00999-10

• A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

  The Journal of Experimental Medicine · 2009 · 10.1084/jem.20082874

• The second messenger bis‐(3′‐5′)‐cyclic‐GMP and its PilZ domain‐containing receptor Alg44 are required for alginate biosynthesis in Pseudomonas aeruginosa

  Molecular Microbiology · 2007 · 10.1111/j.1365-2958.2007.05817.x

• Type I IFN Contributes to NK Cell Homeostasis, Activation, and Antitumor Function

  The Journal of Immunology · 2007 · 10.4049/jimmunol.178.12.7540

• A cyclic‐di‐GMP receptor required for bacterial exopolysaccharide production

  Molecular Microbiology · 2007 · 10.1111/j.1365-2958.2007.05879.x

• NK Cell Maturation and Peripheral Homeostasis Is Associated with KLRG1 Up-Regulation

  The Journal of Immunology · 2007 · 10.4049/jimmunol.178.8.4764

• CD27 Dissects Mature NK Cells into Two Subsets with Distinct Responsiveness and Migratory Capacity

  The Journal of Immunology · 2006 · 10.4049/jimmunol.176.3.1517

• CD4+CD25+ T Regulatory Cells Suppress NK Cell-Mediated Immunotherapy of Cancer

  The Journal of Immunology · 2006 · 10.4049/jimmunol.176.3.1582

• Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3′-5′)-cyclic-GMP in virulence

  Proceedings of the National Academy of Sciences · 2006 · 10.1073/pnas.0511090103

• A nonclassical non-Vα14Jα18 CD1d-restricted (type II) NKT cell is sufficient for down-regulation of tumor immunosurveillance

  The Journal of Experimental Medicine · 2005 · 10.1084/jem.20051381

• Differential antitumor immunity mediated by NKT cell subsets in vivo

  The Journal of Experimental Medicine · 2005 · 10.1084/jem.20050953

• NKG2D function protects the host from tumor initiation

  The Journal of Experimental Medicine · 2005 · 10.1084/jem.20050994

• Activation of NK cell cytotoxicity

  Molecular Immunology · 2004 · 10.1016/j.molimm.2004.07.034

• Cytokines in cancer immunity and immunotherapy

  Immunological Reviews · 2004 · 10.1111/j.0105-2896.2004.00199.x

• IL-21 Induces the Functional Maturation of Murine NK Cells

  The Journal of Immunology · 2004 · 10.4049/jimmunol.172.4.2048

• Nature's TRAIL—On a Path to Cancer Immunotherapy

  Immunity · 2003 · 10.1016/s1074-7613(02)00502-2

• Glycolipid Antigen Drives Rapid Expansion and Sustained Cytokine Production by NK T Cells

  The Journal of Immunology · 2003 · 10.4049/jimmunol.171.8.4020

• New aspects of natural-killer-cell surveillance and therapy of cancer

  Nature reviews. Cancer · 2002 · 10.1038/nrc928

• Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development

  The Journal of Experimental Medicine · 2002 · 10.1084/jem.20011171

• NKT cells — conductors of tumor immunity?

  Current Opinion in Immunology · 2002 · 10.1016/s0952-7915(02)00316-3

• Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells

  Nature Medicine · 2001 · https://doi.org/10.1038/83416

• Critical contribution of liver natural killer T cells to a murine model of hepatitis

  Proceedings of the National Academy of Sciences · 2000 · 10.1073/pnas.040566697

Current projects

No projects listed.