Milton Packer

Research interests

Publications

• Impact of diabetes on the effects of sodium glucose co-transporter-2 inhibitors on kidney outcomes: collaborative meta-analysis of large placebo-controlled trials

  The Lancet · 2022 · https://doi.org/10.1016/s0140-6736(22)02074-8

• Empagliflozin in Heart Failure with a Preserved Ejection Fraction

  New England Journal of Medicine · 2021 · https://doi.org/10.1056/nejmoa2107038

• Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure

  New England Journal of Medicine · 2020 · https://doi.org/10.1056/nejmoa2022190

• SGLT2 inhibitors in patients with heart failure with reduced ejection fraction: a meta-analysis of the EMPEROR-Reduced and DAPA-HF trials

  The Lancet · 2020 · https://doi.org/10.1016/s0140-6736(20)31824-9

• Sacubitril/Valsartan Across the Spectrum of Ejection Fraction in Heart Failure

  Circulation · 2019 · https://doi.org/10.1161/circulationaha.119.044586

• Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction

  New England Journal of Medicine · 2019 · 10.1056/nejmoa1908655

• Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: an individual patient-level analysis of double-blind randomized trials

  European Heart Journal · 2017 · 10.1093/eurheartj/ehx564

• Angiotensin Receptor Neprilysin Inhibition Compared With Enalapril on the Risk of Clinical Progression in Surviving Patients With Heart Failure

  Circulation · 2014 · 10.1161/circulationaha.114.013748

• Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure

  New England Journal of Medicine · 2014 · 10.1056/nejmoa1409077

• Impaired Systolic Function by Strain Imaging in Heart Failure With Preserved Ejection Fraction

  Journal of the American College of Cardiology · 2013 · 10.1016/j.jacc.2013.09.052

• The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial

  The Lancet · 2012 · 10.1016/s0140-6736(12)61227-6

• Levosimendan vs Dobutamine for Patients With Acute Decompensated Heart Failure

  JAMA · 2007 · 10.1001/jama.297.17.1883

• The Seattle Heart Failure Model

  Circulation · 2006 · 10.1161/circulationaha.105.584102

• Targeted Anticytokine Therapy in Patients With Chronic Heart Failure

  Circulation · 2004 · 10.1161/01.cir.0000124490.27666.b2

• Randomized, Double-Blind, Placebo-Controlled, Pilot Trial of Infliximab, a Chimeric Monoclonal Antibody to Tumor Necrosis Factor-α, in Patients With Moderate-to-Severe Heart Failure

  Circulation · 2003 · 10.1161/01.cir.0000077913.60364.d2

• Effect of Carvedilol on the Morbidity of Patients With Severe Chronic Heart Failure

  Circulation · 2002 · 10.1161/01.cir.0000035653.72855.bf

• Cardiac Resynchronization in Chronic Heart Failure

  New England Journal of Medicine · 2002 · 10.1056/nejmoa013168

• Effect of Carvedilol on Survival in Severe Chronic Heart Failure

  New England Journal of Medicine · 2001 · 10.1056/nejm200105313442201

• ACC/AHA Guidelines for the Evaluation and Management of Chronic Heart Failure in the Adult: Executive Summary A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1995 Guidelines for the Evaluation and Management of Heart Failure)

  Circulation · 2001 · 10.1161/hc4901.102568

• ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult: executive summary

  Journal of the American College of Cardiology · 2001 · 10.1016/s0735-1097(01)01683-7

• Comparative Effects of Low and High Doses of the Angiotensin-Converting Enzyme Inhibitor, Lisinopril, on Morbidity and Mortality in Chronic Heart Failure

  Circulation · 1999 · 10.1161/01.cir.100.23.2312

• The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure

  New England Journal of Medicine · 1996 · 10.1056/nejm199605233342101

• Effect of Amlodipine on Morbidity and Mortality in Severe Chronic Heart Failure

  New England Journal of Medicine · 1996 · 10.1056/nejm199610103351504

• The neurohormonal hypothesis: A theory to explain the mechanism of disease progression in heart failure

  Journal of the American College of Cardiology · 1992 · 10.1016/0735-1097(92)90167-l

• Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction

  New England Journal of Medicine · 1992 · 10.1056/nejm199209033271001

• Effect of Oral Milrinone on Mortality in Severe Chronic Heart Failure

  New England Journal of Medicine · 1991 · 10.1056/nejm199111213252103

• Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure

  New England Journal of Medicine · 1990 · 10.1056/nejm199007263230405

Current projects

No projects listed.