Michael R. Stratton

Research interests

Publications

• Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro

  Nature Genetics · 2021 · 10.1038/s41588-021-00972-2

• Somatic mutant clones colonize the human esophagus with age

  Science · 2018 · 10.1126/science.aau3879

• The Repertoire of Mutational Signatures in Human Cancer

  bioRxiv (Cold Spring Harbor Laboratory) · 2018 · https://doi.org/10.1101/322859

• Genomic Evolution of Breast Cancer Metastasis and Relapse

  Cancer Cell · 2017 · https://doi.org/10.1016/j.ccell.2017.07.005

• HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

  Nature Medicine · 2017 · https://doi.org/10.1038/nm.4292

• Universal Patterns of Selection in Cancer and Somatic Tissues

  Cell · 2017 · 10.1016/j.cell.2017.09.042

• Mutational signatures associated with tobacco smoking in human cancer

  Science · 2016 · https://doi.org/10.1126/science.aag0299

• Landscape of somatic mutations in 560 breast cancer whole-genome sequences

  Nature · 2016 · 10.1038/nature17676

• A Landscape of Pharmacogenomic Interactions in Cancer

  Cell · 2016 · https://doi.org/10.1016/j.cell.2016.06.017

• Clock-like mutational processes in human somatic cells

  Nature Genetics · 2015 · 10.1038/ng.3441

• Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

  Cell · 2015 · 10.1016/j.cell.2015.03.053

• Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

  Nature Genetics · 2015 · 10.1038/ng.3252

• High burden and pervasive positive selection of somatic mutations in normal human skin

  Science · 2015 · 10.1126/science.aaa6806

• High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma

  Nature Medicine · 2014 · 10.1038/nm.3773

• COSMIC: exploring the world's knowledge of somatic mutations in human cancer

  Nucleic Acids Research · 2014 · 10.1093/nar/gku1075

• Deciphering Signatures of Mutational Processes Operative in Human Cancer

  Cell Reports · 2013 · 10.1016/j.celrep.2012.12.008

• Signatures of mutational processes in human cancer

  Nature · 2013 · https://doi.org/10.1038/nature12477

• Clinical and biological implications of driver mutations in myelodysplastic syndromes

  Blood · 2013 · 10.1182/blood-2013-08-518886

• Tumor Exome Analysis Reveals Neoantigen-Specific T-Cell Reactivity in an Ipilimumab-Responsive Melanoma

  Journal of Clinical Oncology · 2013 · 10.1200/jco.2012.47.7521

• The landscape of cancer genes and mutational processes in breast cancer

  Nature · 2012 · 10.1038/nature11017

• Systematic identification of genomic markers of drug sensitivity in cancer cells

  Nature · 2012 · 10.1038/nature11005

• Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

  Nucleic Acids Research · 2012 · https://doi.org/10.1093/nar/gks1111

• The Life History of 21 Breast Cancers

  Cell · 2012 · 10.1016/j.cell.2012.04.023

• Mutational Processes Molding the Genomes of 21 Breast Cancers

  Cell · 2012 · 10.1016/j.cell.2012.04.024

• Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

  Nature · 2011 · 10.1038/nature10113

• SomaticSF3B1Mutation in Myelodysplasia with Ring Sideroblasts

  New England Journal of Medicine · 2011 · 10.1056/nejmoa1103283

• Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

  Nature · 2011 · 10.1038/nature09639

• Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

  Cell · 2011 · 10.1016/j.cell.2010.11.055

• Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

  Nature · 2010 · 10.1038/nature08979

• International network of cancer genome projects

  Nature · 2010 · 10.1038/nature08987

• COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

  Nucleic Acids Research · 2010 · 10.1093/nar/gkq929

• The patterns and dynamics of genomic instability in metastatic pancreatic cancer

  Nature · 2010 · 10.1038/nature09460

• Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

  Nature · 2010 · 10.1038/nature08672

• A comprehensive catalogue of somatic mutations from a human cancer genome

  Nature · 2009 · 10.1038/nature08658

• Complex landscapes of somatic rearrangement in human breast cancer genomes

  Nature · 2009 · 10.1038/nature08645

• A small-cell lung cancer genome with complex signatures of tobacco exposure

  Nature · 2009 · 10.1038/nature08629

• The cancer genome

  Nature · 2009 · https://doi.org/10.1038/nature07943

• The Catalogue of Somatic Mutations in Cancer (COSMIC)

  Current Protocols in Human Genetics · 2008 · 10.1002/0471142905.hg1011s57

• JAK2 Exon 12 Mutations in Polycythemia Vera and Idiopathic Erythrocytosis

  New England Journal of Medicine · 2007 · 10.1056/nejmoa065202

• Genome-wide association study identifies novel breast cancer susceptibility loci

  Nature · 2007 · 10.1038/nature05887

• Patterns of somatic mutation in human cancer genomes

  Nature · 2007 · 10.1038/nature05610

• PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

  Nature Genetics · 2006 · 10.1038/ng1959

• Prediction of BRCA1 Status in Patients with Breast Cancer Using Estrogen Receptor and Basal Phenotype

  Clinical Cancer Research · 2005 · 10.1158/1078-0432.ccr-04-2424

• A census of human cancer genes

  Nature reviews. Cancer · 2004 · 10.1038/nrc1299

• Intragenic ERBB2 kinase mutations in tumours

  Nature · 2004 · 10.1038/431525b

• Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations

  Nature Genetics · 2002 · 10.1038/ng879

• BRAF and RAS mutations in human lung cancer and melanoma.

  PubMed · 2002

• Mutations of the BRAF gene in human cancer

  Nature · 2002 · https://doi.org/10.1038/nature00766

• Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families

  The American Journal of Human Genetics · 1998 · 10.1086/301749

• Identification of the breast cancer susceptibility gene BRCA2

  Nature · 1995 · https://doi.org/10.1038/378789a0

• Localization of a Breast Cancer Susceptibility Gene, BRCA2 , to Chromosome 13q12-13

  Science · 1994 · 10.1126/science.8091231

Current projects

No projects listed.