Tom van der Poll

Research interests

Publications

• Redefining critical illness

  Nature Medicine · 2022 · https://doi.org/10.1038/s41591-022-01843-x

• Pneumonia

  Nature Reviews Disease Primers · 2021 · https://doi.org/10.1038/s41572-021-00259-0

• The immunology of sepsis

  Immunity · 2021 · 10.1016/j.immuni.2021.10.012

• Autoantibodies against type I interferons are associated with multi-organ failure in COVID-19 patients

  Intensive Care Medicine · 2021 · https://doi.org/10.1007/s00134-021-06392-4

• Clinical features and prognostic factors in Covid-19: A prospective cohort study

  EBioMedicine · 2021 · https://doi.org/10.1016/j.ebiom.2021.103378

• The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

  The Lancet Respiratory Medicine · 2021 · 10.1016/s2213-2600(21)00218-6

• Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

  Science · 2020 · https://doi.org/10.1126/science.abc8378

• Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis

  JAMA · 2019 · https://doi.org/10.1001/jama.2019.5791

• Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study

  The Lancet Respiratory Medicine · 2017 · https://doi.org/10.1016/s2213-2600(17)30294-1

• A guiding map for inflammation

  Nature Immunology · 2017 · https://doi.org/10.1038/ni.3790

• The immunopathology of sepsis and potential therapeutic targets

  Nature reviews. Immunology · 2017 · https://doi.org/10.1038/nri.2017.36

• Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

  Nature Immunology · 2016 · 10.1038/ni.3398

• The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

  JAMA · 2016 · https://doi.org/10.1001/jama.2016.0287

• Coagulation and sepsis

  Thrombosis Research · 2016 · 10.1016/j.thromres.2016.11.007

• Incidence, Risk Factors, and Attributable Mortality of Secondary Infections in the Intensive Care Unit After Admission for Sepsis

  JAMA · 2016 · 10.1001/jama.2016.2691

• Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients

  Blood · 2016 · https://doi.org/10.1182/blood-2015-11-680744

• A Molecular Host Response Assay to Discriminate Between Sepsis and Infection-Negative Systemic Inflammation in Critically Ill Patients: Discovery and Validation in Independent Cohorts

  PLoS Medicine · 2015 · https://doi.org/10.1371/journal.pmed.1001916

• The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia

  Gut · 2015 · 10.1136/gutjnl-2015-309728

• A Molecular Biomarker to Diagnose Community-acquired Pneumonia on Intensive Care Unit Admission

  American Journal of Respiratory and Critical Care Medicine · 2015 · https://doi.org/10.1164/rccm.201502-0355oc

• The Preventive Antibiotics in Stroke Study (PASS): a pragmatic randomised open-label masked endpoint clinical trial

  The Lancet · 2015 · https://doi.org/10.1016/s0140-6736(14)62456-9

• Sepsis: a roadmap for future research

  The Lancet Infectious Diseases · 2015 · 10.1016/s1473-3099(15)70112-x

• Cross-sectional Comparison of the Prevalence of Age-Associated Comorbidities and Their Risk Factors Between HIV-Infected and Uninfected Individuals: The AGEhIV Cohort Study

  Clinical Infectious Diseases · 2014 · 10.1093/cid/ciu701

• Severe Sepsis and Septic Shock

  New England Journal of Medicine · 2013 · https://doi.org/10.1056/nejmra1208623

• Pathogenesis and Pathophysiology of Pneumococcal Meningitis

  Clinical Microbiology Reviews · 2011 · https://doi.org/10.1128/cmr.00008-11

• Inflammation and coagulation

  Critical Care Medicine · 2010 · 10.1097/ccm.0b013e3181c98d21

• Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit

  Critical Care · 2010 · 10.1186/cc9309

• Pathogenesis, treatment, and prevention of pneumococcal pneumonia

  The Lancet · 2009 · 10.1016/s0140-6736(09)61114-4

• Expression and Role of Myeloid-related Protein-14 in Clinical and Experimental Sepsis

  American Journal of Respiratory and Critical Care Medicine · 2009 · https://doi.org/10.1164/rccm.200810-1552oc

• Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis

  The Lancet Infectious Diseases · 2008 · https://doi.org/10.1016/s1473-3099(08)70261-5

• Inflammation, endothelium, and coagulation in sepsis

  Journal of Leukocyte Biology · 2007 · 10.1189/jlb.0607373

• Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock

  Nature Medicine · 2007 · https://doi.org/10.1038/nm1638

• Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei

  Nature Reviews Microbiology · 2006 · 10.1038/nrmicro1385

• Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney

  Journal of Clinical Investigation · 2005 · 10.1172/jci22832

• Bidirectional Relation Between Inflammation and Coagulation

  Circulation · 2004 · 10.1161/01.cir.0000131660.51520.9a

• The cytokine‐mediated imbalance between coagulant and anticoagulant mechanisms in sepsis and endotoxaemia

  European Journal of Clinical Investigation · 1997 · https://doi.org/10.1046/j.1365-2362.1997.570614.x

• Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees.

  The Journal of Experimental Medicine · 1994 · https://doi.org/10.1084/jem.179.4.1253

• Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees.

  Journal of Clinical Investigation · 1994 · https://doi.org/10.1172/jci116934

• Activation of Coagulation after Administration of Tumor Necrosis Factor to Normal Subjects

  New England Journal of Medicine · 1990 · 10.1056/nejm199006073222302

Current projects

No projects listed.