David M. Sabatini

Research interests

Publications

• mTOR at the nexus of nutrition, growth, ageing and disease

  Nature Reviews Molecular Cell Biology · 2020 · 10.1038/s41580-019-0199-y

• mTOR Signaling in Growth, Metabolism, and Disease

  Cell · 2017 · https://doi.org/10.1016/j.cell.2017.02.004

• Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase

  Cell · 2017 · https://doi.org/10.1016/j.cell.2017.03.023

• High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

  Nature · 2016 · https://doi.org/10.1038/nature17173

• Identification and characterization of essential genes in the human genome

  Science · 2015 · 10.1126/science.aac7041

• A unifying model for mTORC1-mediated regulation of mRNA translation

  Nature · 2012 · 10.1038/nature11083

• mTOR Signaling in Growth Control and Disease

  Cell · 2012 · https://doi.org/10.1016/j.cell.2012.03.017

• mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

  Nature · 2012 · https://doi.org/10.1038/nature11163

• A lysosome‐to‐nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

  The EMBO Journal · 2012 · 10.1038/emboj.2012.32

• Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

  Nature · 2011 · 10.1038/nature10350

• mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H + -ATPase

  Science · 2011 · 10.1126/science.1207056

• mTOR: from growth signal integration to cancer, diabetes and ageing

  Nature Reviews Molecular Cell Biology · 2010 · 10.1038/nrm3025

• Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

  Cell · 2010 · 10.1016/j.cell.2010.02.024

• Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

  Nature · 2009 · https://doi.org/10.1038/nature08460

• An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

  Journal of Biological Chemistry · 2009 · 10.1074/jbc.m900301200

• mTOR signaling at a glance

  Journal of Cell Science · 2009 · 10.1242/jcs.051011

• The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

  Science · 2008 · 10.1126/science.1157535

• Cancer Cell Metabolism: Warburg and Beyond

  Cell · 2008 · 10.1016/j.cell.2008.08.021

• Defining the Role of mTOR in Cancer

  Cancer Cell · 2007 · 10.1016/j.ccr.2007.05.008

• CellProfiler: image analysis software for identifying and quantifying cell phenotypes

  Genome biology · 2006 · https://doi.org/10.1186/gb-2006-7-10-r100

• Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

  Molecular Cell · 2006 · 10.1016/j.molcel.2006.03.029

• A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen

  Cell · 2006 · 10.1016/j.cell.2006.01.040

• Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

  Science · 2005 · https://doi.org/10.1126/science.1106148

• Growing roles for the mTOR pathway

  Current Opinion in Cell Biology · 2005 · 10.1016/j.ceb.2005.09.009

• Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

  Current Biology · 2004 · 10.1016/j.cub.2004.06.054

• Lentivirus-delivered stable gene silencing by RNAi in primary cells

  RNA · 2003 · 10.1261/rna.2192803

• mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

  Cell · 2002 · 10.1016/s0092-8674(02)00808-5

Current projects

No projects listed.