Elias S.J. Arnér

Research interests

Publications

• The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1

  Redox Biology · 2023 · 10.1016/j.redox.2023.102703

• Control of protein function through oxidation and reduction of persulfidated states

  Science Advances · 2020 · 10.1126/sciadv.aax8358

• Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy

  Science Translational Medicine · 2018 · 10.1126/scitranslmed.aaf7444

• Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

  Cell · 2017 · https://doi.org/10.1016/j.cell.2017.11.048

• A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems

  Science Advances · 2016 · 10.1126/sciadv.1500968

• Selenoprotein Gene Nomenclature

  Journal of Biological Chemistry · 2016 · 10.1074/jbc.m116.756155

• Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications

  Physiological Reviews · 2015 · 10.1152/physrev.00010.2014

• TrxR1 as a Potent Regulator of the Nrf2-Keap1 Response System

  Antioxidants and Redox Signaling · 2015 · 10.1089/ars.2015.6378

• ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis

  Cell Death and Differentiation · 2014 · 10.1038/cdd.2013.186

• Selenoproteins—What unique properties can arise with selenocysteine in place of cysteine?

  Experimental Cell Research · 2010 · 10.1016/j.yexcr.2010.02.032

• Focus on mammalian thioredoxin reductases — Important selenoproteins with versatile functions

  Biochimica et Biophysica Acta (BBA) - General Subjects · 2009 · https://doi.org/10.1016/j.bbagen.2009.01.014

• Crystal Structure and Catalysis of the Selenoprotein Thioredoxin Reductase 1

  Journal of Biological Chemistry · 2008 · 10.1074/jbc.m807068200

• Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target

  PLoS Medicine · 2007 · 10.1371/journal.pmed.0040206

• The thioredoxin system in cancer

  Seminars in Cancer Biology · 2006 · https://doi.org/10.1016/j.semcancer.2006.10.009

• Selenocysteine in proteins—properties and biotechnological use

  Biochimica et Biophysica Acta (BBA) - General Subjects · 2005 · 10.1016/j.bbagen.2005.05.010

• Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds

  Free Radical Biology and Medicine · 2005 · 10.1016/j.freeradbiomed.2005.04.025

• Active sites of thioredoxin reductases: Why selenoproteins?

  Proceedings of the National Academy of Sciences · 2003 · 10.1073/pnas.2134510100

• The Mammalian Cytosolic Selenoenzyme Thioredoxin Reductase Reduces Ubiquinone

  Journal of Biological Chemistry · 2003 · 10.1074/jbc.m210456200

• Reactive oxygen species, antioxidants, and the mammalian thioredoxin system1 1This review is based on the licentiate thesis “Thioredoxin reductase—interactions with the redox active compounds 1-chloro-2,4-dinitrobenzene and lipoic acid” by Jonas Nordberg, 2001, Karolinska Institute, Stockholm, ISBN 91-631-1064-4.

  Free Radical Biology and Medicine · 2001 · https://doi.org/10.1016/s0891-5849(01)00724-9

• Physiological functions of thioredoxin and thioredoxin reductase

  European Journal of Biochemistry · 2000 · https://doi.org/10.1046/j.1432-1327.2000.01701.x

• Structure and mechanism of mammalian thioredoxin reductase: The active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence

  Proceedings of the National Academy of Sciences · 2000 · 10.1073/pnas.100114897

• High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA , selB and selC genes 1 1Edited by M. Gottesman

  Journal of Molecular Biology · 1999 · 10.1006/jmbi.1999.3085

• Preparation and assay of mammalian thioredoxin and thioredoxin reductase

  Methods in enzymology on CD-ROM/Methods in enzymology · 1999 · 10.1016/s0076-6879(99)00129-9

• Rat and Calf Thioredoxin Reductase Are Homologous to Glutathione Reductase with a Carboxyl-terminal Elongation Containing a Conserved Catalytically Active Penultimate Selenocysteine Residue

  Journal of Biological Chemistry · 1998 · 10.1074/jbc.273.15.8581

• Mammalian deoxyribonucleoside kinases

  Pharmacology & Therapeutics · 1995 · 10.1016/0163-7258(95)00015-9

Current projects

No projects listed.