Randall S. Johnson

Research interests

Publications

• Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

  Cell · 2014 · https://doi.org/10.1016/j.cell.2014.05.012

• HIF Transcription Factors, Inflammation, and Immunity

  Immunity · 2014 · 10.1016/j.immuni.2014.09.008

• Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen

  Nature Immunology · 2013 · 10.1038/ni.2714

• Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

  Cell stem cell · 2013 · https://doi.org/10.1016/j.stem.2012.10.011

• HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

  Nature reviews. Cancer · 2011 · https://doi.org/10.1038/nrc3183

• Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

  Cell stem cell · 2010 · https://doi.org/10.1016/j.stem.2010.06.020

• Interdependence of hypoxic and innate immune responses

  Nature reviews. Immunology · 2009 · 10.1038/nri2607

• NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

  Nature · 2008 · https://doi.org/10.1038/nature06905

• HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

  Cancer Cell · 2008 · 10.1016/j.ccr.2008.01.034

• Biology of HIF-1α

  Cell Death and Differentiation · 2008 · 10.1038/cdd.2008.12

• Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

  Journal of Clinical Investigation · 2007 · 10.1172/jci30487

• Hypoxia: A key regulator of angiogenesis in cancer

  Cancer and Metastasis Reviews · 2007 · 10.1007/s10555-007-9066-y

• The hypoxia-inducible factor α pathway couples angiogenesis to osteogenesis during skeletal development

  Journal of Clinical Investigation · 2007 · 10.1172/jci31581

• Hypoxia-induced neutrophil survival is mediated by HIF-1α–dependent NF-κB activity

  The Journal of Experimental Medicine · 2005 · 10.1084/jem.20040624

• HIF-1α expression regulates the bactericidal capacity of phagocytes

  Journal of Clinical Investigation · 2005 · 10.1172/jci23865

• HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation

  Cell · 2003 · https://doi.org/10.1016/s0092-8674(03)00154-5

• Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival

  Genes & Development · 2001 · 10.1101/gad.934301

• Loss of PTEN facilitates HIF-1-mediated gene expression

  Genes & Development · 2000 · 10.1101/gad.14.4.391

• Guidelines for using human event‐related potentials to study cognition: Recording standards and publication criteria

  Psychophysiology · 2000 · https://doi.org/10.1111/1469-8986.3720127

• Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.

  PubMed · 2000

• c‐Jun regulates cell cycle progression and apoptosis by distinct mechanisms

  The EMBO Journal · 1999 · 10.1093/emboj/18.1.188

• The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis

  The Journal of Experimental Medicine · 1999 · 10.1084/jem.189.11.1839

• Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB Kinase

  Science · 1999 · 10.1126/science.284.5412.316

• Uncoupling of Obesity from Insulin Resistance Through a Targeted Mutation in aP2 , the Adipocyte Fatty Acid Binding Protein

  Science · 1996 · 10.1126/science.274.5291.1377

• Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

  Nature · 1994 · 10.1038/372186a0

• RAG-1-deficient mice have no mature B and T lymphocytes

  Cell · 1992 · https://doi.org/10.1016/0092-8674(92)90030-g

Current projects

No projects listed.