Peter D. Arkwright

Research interests

Publications

• Dupilumab in children aged 6 months to younger than 6 years with uncontrolled atopic dermatitis: a randomised, double-blind, placebo-controlled, phase 3 trial

  The Lancet · 2022 · 10.1016/s0140-6736(22)01539-2

• Dupilumab in children aged 6 months to younger than 6 years with uncontrolled atopic dermatitis: a randomised, double-blind, placebo-controlled, phase 3 trial

  The Lancet · 2022 · 10.1016/s0140-6736(22)01539-2

• The Risk of Allergic Reaction to SARS-CoV-2 Vaccines and Recommended Evaluation and Management: A Systematic Review, Meta-Analysis, GRADE Assessment, and International Consensus Approach

  The Journal of Allergy and Clinical Immunology In Practice · 2021 · 10.1016/j.jaip.2021.06.006

• Efficacy and safety of dupilumab with concomitant topical corticosteroids in children 6 to 11 years old with severe atopic dermatitis: A randomized, double-blinded, placebo-controlled phase 3 trial

  Journal of the American Academy of Dermatology · 2020 · 10.1016/j.jaad.2020.06.054

• Type 2 immunity in the skin and lungs

  Allergy · 2020 · 10.1111/all.14318

• Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects

  Journal of Allergy and Clinical Immunology · 2018 · https://doi.org/10.1016/j.jaci.2018.02.055

• Hypomorphic caspase activation and recruitment domain 11 (CARD11) mutations associated with diverse immunologic phenotypes with or without atopic disease

  Journal of Allergy and Clinical Immunology · 2018 · https://doi.org/10.1016/j.jaci.2018.08.013

• Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation

  Science · 2018 · 10.1126/science.aar2641

• Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number

  Nature Genetics · 2016 · 10.1038/ng.3696

• The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency

  Journal of Allergy and Clinical Immunology · 2015 · https://doi.org/10.1016/j.jaci.2014.12.1945

• Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies

  Journal of Allergy and Clinical Immunology · 2015 · https://doi.org/10.1016/j.jaci.2015.05.036

• Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

  Science · 2015 · https://doi.org/10.1126/science.aaa4282

• CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation

  Nature · 2014 · 10.1038/nature13386

• Clinical outcome in IL-10– and IL-10 receptor–deficient patients with or without hematopoietic stem cell transplantation

  Journal of Allergy and Clinical Immunology · 2012 · https://doi.org/10.1016/j.jaci.2012.09.025

• Functional STAT3 deficiency compromises the generation of human T follicular helper cells

  Blood · 2012 · 10.1182/blood-2011-11-392985

• Clinical Features That Identify Children With Primary Immunodeficiency Diseases

  PEDIATRICS · 2011 · 10.1542/peds.2010-3680

• DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice

  The Journal of Experimental Medicine · 2011 · https://doi.org/10.1084/jem.20110345

• Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I

  The Journal of Experimental Medicine · 2010 · https://doi.org/10.1084/jem.20091983

• Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome

  Journal of Allergy and Clinical Immunology · 2010 · https://doi.org/10.1016/j.jaci.2009.10.059

• X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency: a multicenter study on the manifestations, management and outcome of the disease

  Blood · 2010 · https://doi.org/10.1182/blood-2010-06-284935

• Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency

  Medicine · 2010 · https://doi.org/10.1097/md.0b013e3181fd8ec3

• B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

  The Journal of Experimental Medicine · 2010 · 10.1084/jem.20091706

• Autoantibodies against Type I Interferons as an Additional Diagnostic Criterion for Autoimmune Polyendocrine Syndrome Type I

  The Journal of Clinical Endocrinology & Metabolism · 2008 · 10.1210/jc.2008-0935

• Novel STAT1 Alleles in Otherwise Healthy Patients with Mycobacterial Disease

  PLoS Genetics · 2006 · https://doi.org/10.1371/journal.pgen.0020131

• Human Complete Stat-1 Deficiency Is Associated with Defective Type I and II IFN Responses In Vitro but Immunity to Some Low Virulence Viruses In Vivo

  The Journal of Immunology · 2006 · https://doi.org/10.4049/jimmunol.176.8.5078

• Autoimmune Lymphoproliferative Syndrome with SomaticFasMutations

  New England Journal of Medicine · 2004 · 10.1056/nejmoa040036

• TGF-beta 1 genotype and accelerated decline in lung function of patients with cystic fibrosis

  Thorax · 2000 · 10.1136/thorax.55.6.459

• Changes in IgG glycoform levels are associated with remission of arthritis during pregnancy

  Journal of Autoimmunity · 1991 · 10.1016/0896-8411(91)90173-a

• Effects of alcohol use and other aspects of lifestyle on blood pressure levels and prevalence of hypertension in a working population.

  Circulation · 1982 · https://doi.org/10.1161/01.cir.66.1.60

Current projects

No projects listed.