Jos Jonkers

Research interests

Publications

• Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

  Nature Genetics · 2021 · https://doi.org/10.1038/s41588-020-00750-6

• ESMO recommendations on predictive biomarker testing for homologous recombination deficiency and PARP inhibitor benefit in ovarian cancer

  Annals of Oncology · 2020 · https://doi.org/10.1016/j.annonc.2020.08.2102

• Long‐term expanding human airway organoids for disease modeling

  The EMBO Journal · 2019 · https://doi.org/10.15252/embj.2018100300

• A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation

  EMBO Molecular Medicine · 2018 · https://doi.org/10.15252/emmm.201809172

• RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer

  Annals of Oncology · 2018 · https://doi.org/10.1093/annonc/mdy099

• Interrogating open issues in cancer precision medicine with patient-derived xenografts

  Nature reviews. Cancer · 2017 · https://doi.org/10.1038/nrc.2016.140

• Landscape of somatic mutations in 560 breast cancer whole-genome sequences

  Nature · 2016 · https://doi.org/10.1038/nature17676

• The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin

  Cancer Research · 2016 · https://doi.org/10.1158/0008-5472.can-16-0186

• IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

  Nature · 2015 · https://doi.org/10.1038/nature14282

• Targeted sequencing by proximity ligation for comprehensive variant detection and local haplotyping

  Nature Biotechnology · 2014 · https://doi.org/10.1038/nbt.2959

• Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

  Cancer Discovery · 2014 · https://doi.org/10.1158/2159-8290.cd-14-0001

• Synergistic tumour suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancer

  Gut · 2011 · https://doi.org/10.1136/gutjnl-2011-300050

• Autotaxin, a Secreted Lysophospholipase D, Is Essential for Blood Vessel Formation during Development

  Molecular and Cellular Biology · 2006 · https://doi.org/10.1128/mcb.02419-05

• Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer

  Nature Genetics · 2001 · https://doi.org/10.1038/ng747

Current projects

No projects listed.