Ton N. Schumacher

Research interests

Publications

• Tertiary lymphoid structures in cancer

  Science · 2022 · 10.1126/science.abf9419

• Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers

  Nature Medicine · 2020 · https://doi.org/10.1038/s41591-020-0805-8

• CD8+ T cell states in human cancer: insights from single-cell analysis

  Nature reviews. Cancer · 2020 · 10.1038/s41568-019-0235-4

• B cells and tertiary lymphoid structures promote immunotherapy response

  Nature · 2020 · https://doi.org/10.1038/s41586-019-1922-8

• The CD47-SIRPα Immune Checkpoint

  Immunity · 2020 · 10.1016/j.immuni.2020.04.011

• Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial

  Nature Medicine · 2019 · https://doi.org/10.1038/s41591-019-0432-4

• Defining ‘T cell exhaustion’

  Nature reviews. Immunology · 2019 · https://doi.org/10.1038/s41577-019-0221-9

• Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

  Cell · 2018 · 10.1016/j.cell.2018.07.009

• Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma

  Nature Medicine · 2018 · https://doi.org/10.1038/s41591-018-0198-0

• Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

  Cell · 2018 · 10.1016/j.cell.2018.11.043

• T Cell Dysfunction in Cancer

  Cancer Cell · 2018 · 10.1016/j.ccell.2018.03.012

• Regulation and Function of the PD-L1 Checkpoint

  Immunity · 2018 · 10.1016/j.immuni.2018.03.014

• A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

  Nature Medicine · 2018 · 10.1038/s41591-018-0057-z

• Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

  Nature · 2017 · 10.1038/nature23669

• The “cancer immunogram”

  Science · 2016 · 10.1126/science.aaf2834

• Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

  New England Journal of Medicine · 2016 · https://doi.org/10.1056/nejmoa1604958

• Neoantigens in cancer immunotherapy

  Science · 2015 · https://doi.org/10.1126/science.aaa4971

• Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

  Science · 2015 · https://doi.org/10.1126/science.aaa1348

• Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

  Nature · 2014 · 10.1038/nature13988

• High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma

  Nature Medicine · 2014 · 10.1038/nm.3773

• Signatures of mutational processes in human cancer

  Nature · 2013 · https://doi.org/10.1038/nature12477

• Tumor Exome Analysis Reveals Neoantigen-Specific T-Cell Reactivity in an Ipilimumab-Responsive Melanoma

  Journal of Clinical Oncology · 2013 · 10.1200/jco.2012.47.7521

• Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

  The Journal of Experimental Medicine · 2001 · 10.1084/jem.194.6.823

• CD27 is required for generation and long-term maintenance of T cell immunity

  Nature Immunology · 2000 · 10.1038/80877

• Empty MHC class I molecules come out in the cold

  Nature · 1990 · 10.1038/346476a0

Current projects

No projects listed.