René Bernards

Research interests

Publications

• Embracing cancer complexity: Hallmarks of systemic disease

  Cell · 2024 · https://doi.org/10.1016/j.cell.2024.02.009

• Evolving therapeutic landscape of advanced hepatocellular carcinoma

  Nature Reviews Gastroenterology & Hepatology · 2022 · 10.1038/s41575-022-00704-9

• Exploiting senescence for the treatment of cancer

  Nature reviews. Cancer · 2022 · 10.1038/s41568-022-00450-9

• 70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer

  New England Journal of Medicine · 2016 · https://doi.org/10.1056/nejmoa1602253

• The consensus molecular subtypes of colorectal cancer

  Nature Medicine · 2015 · https://doi.org/10.1038/nm.3967

• Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

  Nature · 2014 · https://doi.org/10.1038/nature13121

• Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

  Nature · 2012 · 10.1038/nature10868

• Enabling personalized cancer medicine through analysis of gene-expression patterns

  Nature · 2008 · 10.1038/nature06915

• An Integrative Genomic and Proteomic Analysis of PIK3CA, PTEN, and AKT Mutations in Breast Cancer

  Cancer Research · 2008 · https://doi.org/10.1158/0008-5472.can-07-6854

• A Functional Genetic Approach Identifies the PI3K Pathway as a Major Determinant of Trastuzumab Resistance in Breast Cancer

  Cancer Cell · 2007 · 10.1016/j.ccr.2007.08.030

• Regulation of monoubiquitinated PCNA by DUB autocleavage

  Nature Cell Biology · 2006 · 10.1038/ncb1378

• Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

  Nature Cell Biology · 2006 · 10.1038/ncb1448

• A Genomic and Functional Inventory of Deubiquitinating Enzymes

  Cell · 2005 · 10.1016/j.cell.2005.11.007

• The Deubiquitinating Enzyme USP1 Regulates the Fanconi Anemia Pathway

  Molecular Cell · 2005 · 10.1016/j.molcel.2005.01.008

• The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene

  Nature Cell Biology · 2005 · 10.1038/ncb1314

• A large-scale RNAi screen in human cells identifies new components of the p53 pathway

  Nature Cell Biology · 2004 · 10.1038/nature02371

• Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

  Nature · 2003 · 10.1038/nature01811

• Gene expression profiling predicts clinical outcome of breast cancer

  Nature · 2002 · https://doi.org/10.1038/415530a

• A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

  Science · 2002 · https://doi.org/10.1126/science.1068999

• Stable suppression of tumorigenicity by virus-mediated RNA interference

  Cancer Cell · 2002 · 10.1016/s1535-6108(02)00122-8

• A Gene-Expression Signature as a Predictor of Survival in Breast Cancer

  New England Journal of Medicine · 2002 · https://doi.org/10.1056/nejmoa021967

• Metastasis genes: A progression puzzle

  Nature · 2002 · 10.1038/418823a

• CDK-Independent Activation of Estrogen Receptor by Cyclin D1

  Cell · 1997 · 10.1016/s0092-8674(00)81879-6

• A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

  Nature · 1986 · https://doi.org/10.1038/323643a0

• Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells

  Nature · 1983 · 10.1038/305771a0

Current projects

No projects listed.