Relja Popovic

Research interests

Publications

• Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia

  Signal Transduction and Targeted Therapy · 2022 · https://doi.org/10.1038/s41392-021-00870-3

• 5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-Mediated Apoptosis

  Clinical Cancer Research · 2020 · https://doi.org/10.1158/1078-0432.ccr-19-1900

• The role of polygenic risk and susceptibility genes in breast cancer over the course of life

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-020-19966-5

• Genetic architecture of human plasma lipidome and its link to cardiovascular disease

  Nature Communications · 2019 · https://doi.org/10.1038/s41467-019-11954-8

• Venetoclax Combined With Low-Dose Cytarabine for Previously Untreated Patients With Acute Myeloid Leukemia: Results From a Phase Ib/II Study

  Journal of Clinical Oncology · 2019 · https://doi.org/10.1200/jco.18.01600

• Safety and preliminary efficacy of venetoclax with decitabine or azacitidine in elderly patients with previously untreated acute myeloid leukaemia: a non-randomised, open-label, phase 1b study

  The Lancet Oncology · 2018 · https://doi.org/10.1016/s1470-2045(18)30010-x

• Genetic biomarkers of sensitivity and resistance to venetoclax monotherapy in patients with relapsed acute myeloid leukemia

  American Journal of Hematology · 2018 · https://doi.org/10.1002/ajh.25146

• UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition

  Cell Reports · 2017 · https://doi.org/10.1016/j.celrep.2017.09.078

• Histone Methyltransferase MMSET/NSD2 Alters EZH2 Binding and Reprograms the Myeloma Epigenome through Global and Focal Changes in H3K36 and H3K27 Methylation

  PLoS Genetics · 2014 · https://doi.org/10.1371/journal.pgen.1004566

• Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies

  Leukemia · 2013 · https://doi.org/10.1038/leu.2013.204

• EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation

  Cancer Cell · 2013 · https://doi.org/10.1016/j.ccr.2013.04.011

• Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3

  Proceedings of the National Academy of Sciences · 2012 · https://doi.org/10.1073/pnas.1205707109

• The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial–mesenchymal transition and invasive properties of prostate cancer

  Oncogene · 2012 · https://doi.org/10.1038/onc.2012.297

• Emerging Epigenetic Targets and Therapies in Cancer Medicine

  Cancer Discovery · 2012 · https://doi.org/10.1158/2159-8290.cd-12-0076

• The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells

  Blood · 2010 · https://doi.org/10.1182/blood-2010-07-298349

• Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization

  Blood · 2009 · https://doi.org/10.1182/blood-2008-04-154310

• Structure of the MLL CXXC domain–DNA complex and its functional role in MLL-AF9 leukemia

  Nature Structural & Molecular Biology · 2009 · https://doi.org/10.1038/nsmb.1714

Current projects

No projects listed.