John Bertin

Research interests

Publications

• Design of amidobenzimidazole STING receptor agonists with systemic activity

  Nature · 2018 · 10.1038/s41586-018-0705-y

• Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

  Science · 2018 · 10.1126/science.aau2818

• Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

  Stroke · 2017 · 10.1161/strokeaha.116.015609

• Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

  Journal of Medicinal Chemistry · 2017 · 10.1021/acs.jmedchem.6b01751

• RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus

  Cell Host & Microbe · 2016 · 10.1016/j.chom.2016.05.011

• NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling

  Molecular Cell · 2015 · 10.1016/j.molcel.2015.07.032

• MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

  Cell Reports · 2014 · 10.1016/j.celrep.2014.04.026

• Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

  The Journal of Immunology · 2014 · 10.4049/jimmunol.1400499

• RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity

  Molecular Cell · 2014 · 10.1016/j.molcel.2014.10.021

• Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

  Journal of Biological Chemistry · 2013 · 10.1074/jbc.m113.462341

• NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens

  Nature · 2012 · 10.1038/nature11250

• The NLRP12 Inflammasome Recognizes Yersinia pestis

  Immunity · 2012 · 10.1016/j.immuni.2012.07.006

• NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

  Cell · 2011 · https://doi.org/10.1016/j.cell.2011.04.022

• A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis

  The Journal of Immunology · 2011 · 10.4049/jimmunol.1100412

• The NOD-Like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis

  Cancer Cell · 2011 · 10.1016/j.ccr.2011.10.022

• The NLR Gene Family: A Standard Nomenclature

  Immunity · 2008 · https://doi.org/10.1016/j.immuni.2008.02.005

• A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system

  Proceedings of the National Academy of Sciences · 2007 · 10.1073/pnas.0609672104

• Critical Role for NALP3/CIAS1/Cryopyrin in Innate and Adaptive Immunity through Its Regulation of Caspase-1

  Immunity · 2006 · https://doi.org/10.1016/j.immuni.2006.02.004

• Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

  Nature · 2006 · https://doi.org/10.1038/nature04517

• Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

  Nature Immunology · 2006 · https://doi.org/10.1038/ni1346

• Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

  Nature Immunology · 2004 · 10.1038/ni1131

• Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan

  Science · 2003 · 10.1126/science.1084677

• PYPAF7, a Novel PYRIN-containing Apaf1-like Protein That Regulates Activation of NF-κB and Caspase-1-dependent Cytokine Processing

  Journal of Biological Chemistry · 2002 · 10.1074/jbc.m203915200

• CARD4/Nod1 mediates NF‐κB and JNK activation by invasive Shigella flexneri

  EMBO Reports · 2001 · 10.1093/embo-reports/kve155

• Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

  Proceedings of the National Academy of Sciences · 1997 · 10.1073/pnas.94.4.1172

Current projects

No projects listed.