Jef D. Boeke

Research interests

Publications

• Results of Two Cases of Pig-to-Human Kidney Xenotransplantation

  New England Journal of Medicine · 2022 · https://doi.org/10.1056/nejmoa2120238

• L1 drives IFN in senescent cells and promotes age-associated inflammation

  Nature · 2019 · https://doi.org/10.1038/s41586-018-0784-9

• Design of a synthetic yeast genome

  Science · 2017 · https://doi.org/10.1126/science.aaf4557

• Total Synthesis of a Functional Designer Eukaryotic Chromosome

  Science · 2014 · https://doi.org/10.1126/science.1249252

• Lysine Succinylation and Lysine Malonylation in Histones

  Molecular & Cellular Proteomics · 2012 · https://doi.org/10.1074/mcp.m111.015875

• Synthetic chromosome arms function in yeast and generate phenotypic diversity by design

  Nature · 2011 · https://doi.org/10.1038/nature10403

• A DNA Integrity Network in the Yeast Saccharomyces cerevisiae

  Cell · 2006 · https://doi.org/10.1016/j.cell.2005.12.036

• The Biochemistry of Sirtuins

  Annual Review of Biochemistry · 2006 · https://doi.org/10.1146/annurev.biochem.74.082803.133500

• Transcriptional disruption by the L1 retrotransposon and implications for mammalian transcriptomes

  Nature · 2004 · https://doi.org/10.1038/nature02536

• Functional profiling of the Saccharomyces cerevisiae genome

  Nature · 2002 · https://doi.org/10.1038/nature00935

• SIRT3, a human SIR2 homologue, is an NAD- dependent deacetylase localized to mitochondria

  Proceedings of the National Academy of Sciences · 2002 · https://doi.org/10.1073/pnas.222538099

• Human L1 Retrotransposition: cis Preference versus trans Complementation

  Molecular and Cellular Biology · 2001 · https://doi.org/10.1128/mcb.21.4.1429-1439.2001

• A phylogenetically conserved NAD + -dependent protein deacetylase activity in the Sir2 protein family

  Proceedings of the National Academy of Sciences · 2000 · https://doi.org/10.1073/pnas.97.12.6658

• Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis

  Science · 1999 · https://doi.org/10.1126/science.285.5429.901

• Transposable Elements and Genome Organization: A Comprehensive Survey of Retrotransposons Revealed by the Complete Saccharomyces cerevisiae Genome Sequence

  Genome Research · 1998 · https://doi.org/10.1101/gr.8.5.464

• Designer deletion strains derived fromSaccharomyces cerevisiae S288C: A useful set of strains and plasmids for PCR-mediated gene disruption and other applications

  Yeast · 1998 · https://doi.org/10.1002/(sici)1097-0061(19980130)14:2<115::aid-yea204>3.0.co;2-2

• An unusual form of transcriptional silencing in yeast ribosomal DNA.

  Genes & Development · 1997 · https://doi.org/10.1101/gad.11.2.241

• High Frequency Retrotransposition in Cultured Mammalian Cells

  Cell · 1996 · https://doi.org/10.1016/s0092-8674(00)81998-4

• Human L1 Retrotransposon Encodes a Conserved Endonuclease Required for Retrotransposition

  Cell · 1996 · https://doi.org/10.1016/s0092-8674(00)81997-2

• The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.

  Genes & Development · 1995 · https://doi.org/10.1101/gad.9.23.2888

• Reverse Transcriptase Encoded by a Human Transposable Element

  Science · 1991 · https://doi.org/10.1126/science.1722352

• [20] In vitro mutagenesis and plasmid shuffling: From cloned gene to mutant yeast

  Methods in enzymology on CD-ROM/Methods in enzymology · 1991 · https://doi.org/10.1016/0076-6879(91)94023-6

• [10] 5-Fluoroorotic acid as a selective agent in yeast molecular genetics

  Methods in enzymology on CD-ROM/Methods in enzymology · 1987 · https://doi.org/10.1016/0076-6879(87)54076-9

• Ty elements transpose through an RNA intermediate

  Cell · 1985 · https://doi.org/10.1016/0092-8674(85)90197-7

• A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance

  Molecular and General Genetics MGG · 1984 · https://doi.org/10.1007/bf00330984

Current projects

No projects listed.