Yasushi Totoki

Research interests

Publications

• Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma

  Cancer Discovery · 2017 · https://doi.org/10.1158/2159-8290.cd-17-0368

• Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3547

• Mutational signatures associated with tobacco smoking in human cancer

  Science · 2016 · https://doi.org/10.1126/science.aag0299

• Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers

  Nature · 2016 · 10.1038/nature18294

• Genomic Sequencing Identifies ELF3 as a Driver of Ampullary Carcinoma

  Cancer Cell · 2016 · 10.1016/j.ccell.2015.12.012

• Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment

  Nature Communications · 2016 · 10.1038/ncomms13616

• Clinical utility of circulating tumor DNA for molecular assessment in pancreatic cancer

  Scientific Reports · 2015 · 10.1038/srep18425

• Integrated molecular analysis of adult T cell leukemia/lymphoma

  Nature Genetics · 2015 · https://doi.org/10.1038/ng.3415

• Genomic spectra of biliary tract cancer

  Nature Genetics · 2015 · https://doi.org/10.1038/ng.3375

• A Novel CIC-FOXO4 Gene Fusion in Undifferentiated Small Round Cell Sarcoma

  The American Journal of Surgical Pathology · 2014 · 10.1097/pas.0000000000000286

• Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

  Nature Genetics · 2014 · 10.1038/ng.3126

• Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma

  Hepatology · 2013 · 10.1002/hep.26890

• Signatures of mutational processes in human cancer

  Nature · 2013 · https://doi.org/10.1038/nature12477

• KIF5B-RET fusions in lung adenocarcinoma

  Nature Medicine · 2012 · 10.1038/nm.2644

• Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators

  Nature Genetics · 2012 · 10.1038/ng.2291

• Role for piRNAs and Noncoding RNA in de Novo DNA Methylation of the Imprinted Mouse Rasgrf1 Locus

  Science · 2011 · 10.1126/science.1203919

• MITOPLD Is a Mitochondrial Protein Essential for Nuage Formation and piRNA Biogenesis in the Mouse Germline

  Developmental Cell · 2011 · 10.1016/j.devcel.2011.01.005

• High-resolution characterization of a hepatocellular carcinoma genome

  Nature Genetics · 2011 · 10.1038/ng.804

• International network of cancer genome projects

  Nature · 2010 · https://doi.org/10.1038/nature08987

• MVH in piRNA processing and gene silencing of retrotransposons

  Genes & Development · 2010 · 10.1101/gad.1902110

• DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes

  Genes & Development · 2008 · 10.1101/gad.1640708

• Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes

  Nature · 2008 · 10.1038/nature06908

• The DNA sequence of human chromosome 21

  Nature · 2000 · https://doi.org/10.1038/35012518

Current projects

No projects listed.