Kendall A. Smith

Research interests

Publications

• PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program

  Nature · 2022 · 10.1038/s41586-022-05257-0

• Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2

  Nature · 2019 · 10.1038/s41586-019-1082-x

• PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells

  Journal of Clinical Investigation · 2013 · 10.1172/jci67008

• Prolonged Interleukin-2Rα Expression on Virus-Specific CD8+ T Cells Favors Terminal-Effector Differentiation In Vivo

  Immunity · 2010 · 10.1016/j.immuni.2009.11.010

• Single‐cell quantification of IL‐2 response by effector and regulatory T cells reveals critical plasticity in immune response

  Molecular Systems Biology · 2010 · 10.1038/msb.2010.90

• Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor

  Proceedings of the National Academy of Sciences · 2006 · 10.1073/pnas.0511161103

• Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo

  Nature Medicine · 2003 · 10.1038/nm866

• Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

  Nature Medicine · 1999 · https://doi.org/10.1038/8394

• Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory.

  The Journal of Experimental Medicine · 1991 · 10.1084/jem.173.1.25

• Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors.

  The Journal of Experimental Medicine · 1990 · 10.1084/jem.171.5.1509

• Interleukin-2: Inception, Impact, and Implications

  Science · 1988 · https://doi.org/10.1126/science.3131876

• The interleukin 2 receptor. Functional consequences of its bimolecular structure.

  The Journal of Experimental Medicine · 1987 · 10.1084/jem.166.4.1055

• Interleukin-2 Induction of T-Cell G 1 Progression and c- myb Expression

  Science · 1986 · 10.1126/science.3523754

• Interleukin 2

  Annual Review of Immunology · 1984 · 10.1146/annurev.iy.02.040184.001535

• The Interleukin-2 T-Cell System: A New Cell Growth Model

  Science · 1984 · 10.1126/science.6427923

• Production and characterization of monoclonal antibodies to human interleukin 2: strategy and tactics.

  The Journal of Immunology · 1983 · 10.4049/jimmunol.131.4.1808

• Transient expression of interleukin 2 receptors. Consequences for T cell growth.

  The Journal of Experimental Medicine · 1983 · 10.1084/jem.158.6.1895

• A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor

  Nature · 1982 · https://doi.org/10.1038/300267a0

• T‐Cell Growth Factor

  Immunological Reviews · 1980 · 10.1111/j.1600-065x.1980.tb00327.x

• Glucocorticoid-Induced Inhibition of T Cell Growth Factor Production

  The Journal of Immunology · 1979 · 10.4049/jimmunol.123.4.1624

• Glucocorticoid-induced inhibition of T cell growth factor production. I. The effect on mitogen-induced lymphocyte proliferation.

  PubMed · 1979

• Biochemical and biological characterization of lymphocyte regulatory molecules. I. Purification of a class of murine lymphokines.

  The Journal of Experimental Medicine · 1979 · 10.1084/jem.150.4.849

• Glucocorticoid-induced inhibition of T cell growth factor production. II. The effect on the in vitro generation of cytolytic T cells.

  PubMed · 1979

• T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

  The Journal of Immunology · 1978 · https://doi.org/10.4049/jimmunol.120.6.2027

• Long term culture of tumour-specific cytotoxic T cells

  Nature · 1977 · https://doi.org/10.1038/268154a0

Current projects

No projects listed.