Divij Mathew

Research interests

Publications

• Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer

  Cancer Cell · 2024 · 10.1016/j.ccell.2023.12.013

• Combined JAK inhibition and PD-1 immunotherapy for non–small cell lung cancer patients

  Science · 2024 · https://doi.org/10.1126/science.adf1329

• Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure

  Immunity · 2023 · 10.1016/j.immuni.2023.11.005

• Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

  Cell · 2022 · https://doi.org/10.1016/j.cell.2022.04.009

• Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics

  Nature Immunology · 2022 · https://doi.org/10.1038/s41590-022-01338-4

• CD8+ T cells contribute to survival in patients with COVID-19 and hematologic cancer

  Nature Medicine · 2021 · https://doi.org/10.1038/s41591-021-01386-7

• Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection

  Cell · 2021 · https://doi.org/10.1016/j.cell.2021.02.010

• Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation

  Nature Immunology · 2021 · https://doi.org/10.1038/s41590-021-00975-5

• Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19

  Science Immunology · 2021 · https://doi.org/10.1126/sciimmunol.abf7570

• In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer

  Cell · 2021 · https://doi.org/10.1016/j.cell.2021.02.019

• Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination

  Science Immunology · 2021 · https://doi.org/10.1126/sciimmunol.abi6950

• mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern

  Science · 2021 · https://doi.org/10.1126/science.abm0829

• Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy

  Nature Medicine · 2021 · https://doi.org/10.1038/s41591-021-01507-2

• Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination

  Immunity · 2021 · https://doi.org/10.1016/j.immuni.2021.08.001

• SARS-CoV-2 seroprevalence among parturient women in Philadelphia

  Science Immunology · 2020 · https://doi.org/10.1126/sciimmunol.abd5709

• Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

  Science · 2020 · https://doi.org/10.1126/science.abc8511

• Comprehensive mapping of immune perturbations associated with severe COVID-19

  Science Immunology · 2020 · https://doi.org/10.1126/sciimmunol.abd7114

• Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency

  Journal of Clinical Investigation · 2015 · 10.1172/jci80477

Current projects

No projects listed.