Gil McVean

Research interests

Publications

• The UK Biobank resource with deep phenotyping and genomic data

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0579-z

• Genome-wide genetic data on ~500,000 UK Biobank participants

  bioRxiv (Cold Spring Harbor Laboratory) · 2017 · 10.1101/166298

• Efficient Coalescent Simulation and Genealogical Analysis for Large Sample Sizes

  PLoS Computational Biology · 2016 · 10.1371/journal.pcbi.1004842

• A global reference for human genetic variation

  Civil War Book Review · 2015

• Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis

  Nature Communications · 2015 · https://doi.org/10.1038/ncomms10063

• Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel

  Nature Communications · 2014 · https://doi.org/10.1038/ncomms4934

• Integrating mapping-, assembly- and haplotype-based approaches for calling variants in clinical sequencing applications

  Nature Genetics · 2014 · https://doi.org/10.1038/ng.3036

• Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

  Nature Genetics · 2013 · 10.1038/ng.2770

• De novo assembly and genotyping of variants using colored de Bruijn graphs

  Nature Genetics · 2012 · 10.1038/ng.1028

• Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

  Nature Genetics · 2012 · 10.1038/ng.2503

• Demographic history and rare allele sharing among human populations

  Proceedings of the National Academy of Sciences · 2011 · 10.1073/pnas.1019276108

• The variant call format and VCFtools

  Bioinformatics · 2011 · https://doi.org/10.1093/bioinformatics/btr330

• Detecting Novel Associations in Large Data Sets

  Science · 2011 · https://doi.org/10.1126/science.1205438

• Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

  Nature · 2011 · 10.1038/nature10251

• Mapping copy number variation by population-scale genome sequencing

  Nature · 2011 · 10.1038/nature09708

• Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

  Nature Genetics · 2011 · 10.1038/ng.873

• Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

  Nature · 2010 · 10.1038/nature08979

• Integrating common and rare genetic variation in diverse human populations

  Nature · 2010 · https://doi.org/10.1038/nature09298

• A Genealogical Interpretation of Principal Components Analysis

  PLoS Genetics · 2009 · 10.1371/journal.pgen.1000686

• Drive Against Hotspot Motifs in Primates Implicates the PRDM9 Gene in Meiotic Recombination

  Science · 2009 · 10.1126/science.1182363

• A new multipoint method for genome-wide association studies by imputation of genotypes

  Nature Genetics · 2007 · 10.1038/ng2088

• A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC

  Nature Genetics · 2006 · 10.1038/ng1885

• A Fine-Scale Map of Recombination Rates and Hotspots Across the Human Genome

  Science · 2005 · 10.1126/science.1117196

• The Fine-Scale Structure of Recombination Rate Variation in the Human Genome

  Science · 2004 · 10.1126/science.1092500

• The International HapMap Project

  Nature · 2003 · https://doi.org/10.1038/nature02168

• A Coalescent-Based Method for Detecting and Estimating Recombination From Gene Sequences

  Genetics · 2002 · 10.1093/genetics/160.3.1231

Current projects

No projects listed.