Fiona Powrie

Research interests

Publications

• The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

  Immunity · 2019 · 10.1016/j.immuni.2018.12.018

• Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease

  Immunity · 2019 · 10.1016/j.immuni.2019.03.017

• Innate Lymphoid Cells: 10 Years On

  Cell · 2018 · https://doi.org/10.1016/j.cell.2018.07.017

• Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease

  Nature Medicine · 2017 · 10.1038/nm.4307

• Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

  Nature Genetics · 2015 · https://doi.org/10.1038/ng.3304

• The alarmin IL-33 promotes regulatory T-cell function in the intestine

  Nature · 2014 · https://doi.org/10.1038/nature13577

• Innate lymphoid cells — a proposal for uniform nomenclature

  Nature reviews. Immunology · 2013 · https://doi.org/10.1038/nri3365

• IL-23–responsive innate lymphoid cells are increased in inflammatory bowel disease

  The Journal of Experimental Medicine · 2011 · 10.1084/jem.20101712

• Intestinal homeostasis and its breakdown in inflammatory bowel disease

  Nature · 2011 · https://doi.org/10.1038/nature10208

• Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis

  Immunity · 2010 · 10.1016/j.immuni.2010.05.003

• Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

  Nature · 2010 · 10.1038/nature08949

• Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans

  The Journal of Experimental Medicine · 2008 · 10.1084/jem.20080414

• Dendritic cells in intestinal immune regulation

  Nature reviews. Immunology · 2008 · 10.1038/nri2335

• A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

  The Journal of Experimental Medicine · 2007 · 10.1084/jem.20070590

• Differential Activity of IL-12 and IL-23 in Mucosal and Systemic Innate Immune Pathology

  Immunity · 2006 · 10.1016/j.immuni.2006.05.017

• Interleukin-23 drives innate and T cell–mediated intestinal inflammation

  The Journal of Experimental Medicine · 2006 · 10.1084/jem.20061099

• Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level

  European Journal of Immunology · 2005 · 10.1002/eji.200526189

• Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells

  The Journal of Immunology · 2003 · 10.4049/jimmunol.170.8.3939

• CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms

  The Journal of Experimental Medicine · 2003 · 10.1084/jem.20021345

• IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo

  The Journal of Immunology · 2001 · 10.4049/jimmunol.166.6.3789

• Regulatory T cells in the control of immune pathology

  Nature Immunology · 2001 · 10.1038/ni0901-816

• Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

  The Journal of Experimental Medicine · 2000 · 10.1084/jem.192.2.295

• An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

  The Journal of Experimental Medicine · 1999 · 10.1084/jem.190.7.995

• A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

  The Journal of Experimental Medicine · 1996 · 10.1084/jem.183.6.2669

• Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

  The Journal of Experimental Medicine · 1994 · 10.1084/jem.179.2.589

• Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

  Immunity · 1994 · 10.1016/1074-7613(94)90045-0

Current projects

No projects listed.