Roger Woodgate

Research interests

Publications

• Translesion DNA polymerases in eukaryotes: what makes them tick?

  Critical Reviews in Biochemistry and Molecular Biology · 2017 · 10.1080/10409238.2017.1291576

• Translesion DNA Polymerases

  Cold Spring Harbor Perspectives in Biology · 2013 · 10.1101/cshperspect.a010363

• Y-family DNA polymerases and their role in tolerance of cellular DNA damage

  Nature Reviews Molecular Cell Biology · 2012 · https://doi.org/10.1038/nrm3289

• What a difference a decade makes: Insights into translesion DNA synthesis

  Proceedings of the National Academy of Sciences · 2007 · 10.1073/pnas.0704219104

• Controlling the subcellular localization of DNA polymerases ι and η via interactions with ubiquitin

  The EMBO Journal · 2006 · 10.1038/sj.emboj.7601178

• Human DNA Polymerase η Promotes DNA Synthesis from Strand Invasion Intermediates of Homologous Recombination

  Molecular Cell · 2005 · 10.1016/j.molcel.2005.10.001

• MSH2–MSH6 stimulates DNA polymerase η, suggesting a role for A:T mutations in antibody genes

  The Journal of Experimental Medicine · 2005 · 10.1084/jem.20042066

• Snapshots of Replication through an Abasic Lesion

  Molecular Cell · 2004 · 10.1016/s1097-2765(04)00101-7

• Replication of a cis–syn thymine dimer at atomic resolution

  Nature · 2003 · 10.1038/nature01919

• Eukaryotic DNA Polymerases: Proposal for a Revised Nomenclature

  Journal of Biological Chemistry · 2001 · 10.1074/jbc.r100056200

• Molecular Analysis of Antibiotic Resistance Gene Clusters in Vibrio cholerae O139 and O1 SXT Constins

  Antimicrobial Agents and Chemotherapy · 2001 · 10.1128/aac.45.11.2991-3000.2001

• 5'-Deoxyribose Phosphate Lyase Activity of Human DNA Polymerase ɩ in Vitro

  Science · 2001 · 10.1126/science.1058386

• Crystal Structure of a Y-Family DNA Polymerase in Action

  Cell · 2001 · 10.1016/s0092-8674(01)00515-3

• The Y-Family of DNA Polymerases

  Molecular Cell · 2001 · https://doi.org/10.1016/s1097-2765(01)00278-7

• polι, a remarkably error-prone human DNA polymerase

  Genes & Development · 2000 · 10.1101/gad.14.13.1642

• Misinsertion and bypass of thymine–thymine dimers by human DNA polymerase ι

  The EMBO Journal · 2000 · 10.1093/emboj/19.19.5259

• Roles of E. coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesis

  Nature · 2000 · 10.1038/35010020

• Identification of additional genes belonging to the LexA regulon in Escherichia coli

  Molecular Microbiology · 2000 · 10.1046/j.1365-2958.2000.01826.x

• UmuD′ 2 C is an error-prone DNA polymerase, Escherichia coli pol V

  Proceedings of the National Academy of Sciences · 1999 · 10.1073/pnas.96.16.8919

• A plethora of lesion-replicating DNA polymerases

  Genes & Development · 1999 · 10.1101/gad.13.17.2191

• Biochemical basis of SOS-induced mutagenesis in Escherichia coli : Reconstitution of in vitro lesion bypass dependent on the UmuD′ 2 C mutagenic complex and RecA protein

  Proceedings of the National Academy of Sciences · 1998 · 10.1073/pnas.95.17.9755

• The Saccharomyces cerevisiae RAD30 Gene, a Homologue of Escherichia coli dinB and umuC, Is DNA Damage Inducible and Functions in a Novel Error-Free Postreplication Repair Mechanism

  Genetics · 1997 · 10.1093/genetics/147.4.1557

• Activity of the purified mutagenesis proteins UmuC, UmuD', and RecA in replicative bypass of an abasic DNA lesion by DNA polymerase III.

  Proceedings of the National Academy of Sciences · 1992 · 10.1073/pnas.89.22.10777

• UmuC mutagenesis protein of Escherichia coli: purification and interaction with UmuD and UmuD'.

  Proceedings of the National Academy of Sciences · 1989 · 10.1073/pnas.86.19.7301

• UmuD mutagenesis protein of Escherichia coli: overproduction, purification, and cleavage by RecA.

  Proceedings of the National Academy of Sciences · 1988 · 10.1073/pnas.85.6.1811

Current projects

No projects listed.