Cory M. Johannessen

Research interests

Publications

• Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers

  Nature Genetics · 2021 · https://doi.org/10.1038/s41588-021-00967-z

• Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies

  Cancer Cell · 2019 · 10.1016/j.ccell.2019.08.005

• Next-generation characterization of the Cancer Cell Line Encyclopedia

  Nature · 2019 · https://doi.org/10.1038/s41586-019-1186-3

• Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling

  Cancer Cell · 2018 · 10.1016/j.ccell.2018.11.005

• Mutational processes shape the landscape of TP53 mutations in human cancer

  Nature Genetics · 2018 · 10.1038/s41588-018-0204-y

• A Convergence-Based Framework for Cancer Drug Resistance

  Cancer Cell · 2018 · https://doi.org/10.1016/j.ccell.2018.03.025

• Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors

  Nature Communications · 2017 · https://doi.org/10.1038/s41467-017-00965-y

• Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants

  Cell Reports · 2016 · https://doi.org/10.1016/j.celrep.2016.09.061

• Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

  Science · 2016 · https://doi.org/10.1126/science.aad0501

• Characterizing genomic alterations in cancer by complementary functional associations

  Nature Biotechnology · 2016 · 10.1038/nbt.3527

• A Functional Landscape of Resistance to ALK Inhibition in Lung Cancer

  Cancer Cell · 2015 · https://doi.org/10.1016/j.ccell.2015.02.005

• A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors

  Cancer Discovery · 2014 · 10.1158/2159-8290.cd-13-0424

• MAP Kinase Pathway Alterations in BRAF -Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

  Cancer Discovery · 2013 · 10.1158/2159-8290.cd-13-0631

• A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

  Nature · 2013 · 10.1038/nature12688

• The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma

  Cancer Discovery · 2013 · https://doi.org/10.1158/2159-8290.cd-13-0617

• A public genome-scale lentiviral expression library of human ORFs

  Nature Methods · 2011 · 10.1038/nmeth.1638

• Dissecting Therapeutic Resistance to RAF Inhibition in Melanoma by Tumor Genomic Profiling

  Journal of Clinical Oncology · 2011 · https://doi.org/10.1200/jco.2010.33.2312

• COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

  Nature · 2010 · 10.1038/nature09627

• TORC1 Is Essential for NF1-Associated Malignancies

  Current Biology · 2008 · https://doi.org/10.1016/j.cub.2007.11.066

• Tumor-Specific p73 Up-regulation Mediates p63 Dependence in Squamous Cell Carcinoma

  Cancer Research · 2006 · 10.1158/0008-5472.can-06-1619

• A negative feedback signaling network underlies oncogene-induced senescence

  Cancer Cell · 2006 · 10.1016/j.ccr.2006.10.003

• Regulation of mTOR and Cell Growth in Response to Energy Stress by REDD1

  Molecular and Cellular Biology · 2005 · 10.1128/mcb.25.14.5834-5845.2005

• The NF1 tumor suppressor critically regulates TSC2 and mTOR

  Proceedings of the National Academy of Sciences · 2005 · 10.1073/pnas.0503224102

• REDD1, a Developmentally Regulated Transcriptional Target of p63 and p53, Links p63 to Regulation of Reactive Oxygen Species

  Molecular Cell · 2002 · 10.1016/s1097-2765(02)00706-2

• Mechanisms of action of valproate: a commentatory

  Neurochemistry International · 2000 · 10.1016/s0197-0186(00)00013-9

Current projects

No projects listed.