Jean‐Christophe Marine

Research interests

Publications

• CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours

  Nature · 2023 · 10.1038/s41586-023-06199-x

• Non-genetic mechanisms of therapeutic resistance in cancer

  Nature reviews. Cancer · 2020 · 10.1038/s41568-020-00302-4

• Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma

  Nature Cell Biology · 2020 · 10.1038/s41556-020-0547-3

• Melanoma plasticity and phenotypic diversity: therapeutic barriers and opportunities

  Genes & Development · 2019 · 10.1101/gad.329771.119

• Toward Minimal Residual Disease-Directed Therapy in Melanoma

  Cell · 2018 · https://doi.org/10.1016/j.cell.2018.06.025

• Identification of the tumour transition states occurring during EMT

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0040-3

• Codon-specific translation reprogramming promotes resistance to targeted therapy

  Nature · 2018 · 10.1038/s41586-018-0243-7

• SCENIC: single-cell regulatory network inference and clustering

  Nature Methods · 2017 · https://doi.org/10.1038/nmeth.4463

• Interrogating open issues in cancer precision medicine with patient-derived xenografts

  Nature reviews. Cancer · 2017 · https://doi.org/10.1038/nrc.2016.140

• p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity

  Nature Medicine · 2016 · 10.1038/nm.4135

• Melanoma addiction to the long non-coding RNA SAMMSON

  Nature · 2016 · https://doi.org/10.1038/nature17161

• Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state

  Nature Communications · 2015 · 10.1038/ncomms7683

• iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track Collections

  PLoS Computational Biology · 2014 · https://doi.org/10.1371/journal.pcbi.1003731

• MDM4 is a key therapeutic target in cutaneous melanoma

  Nature Medicine · 2012 · 10.1038/nm.2863

• Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

  Nature Chemical Biology · 2011 · 10.1038/nchembio.546

• The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

  Genes & Development · 2007 · https://doi.org/10.1101/gad.415507

• Inactivation of the p53 pathway in retinoblastoma

  Nature · 2006 · 10.1038/nature05194

• Amplification of Mdmx (or Mdm4 ) Directly Contributes to Tumor Formation by Inhibiting p53 Tumor Suppressor Activity

  Molecular and Cellular Biology · 2004 · 10.1128/mcb.24.13.5835-5843.2004

• Mdm4 (Mdmx) Regulates p53-Induced Growth Arrest and Neuronal Cell Death during Early Embryonic Mouse Development

  Molecular and Cellular Biology · 2002 · 10.1128/mcb.22.15.5527-5538.2002

• Nucleophosmin regulates the stability and transcriptional activity of p53

  Nature Cell Biology · 2002 · 10.1038/ncb814

• The Ornithine Decarboxylase Gene Is Essential for Cell Survival during Early Murine Development

  Molecular and Cellular Biology · 2001 · 10.1128/mcb.21.19.6549-6558.2001

• Phospholipase Cγ2 Is Essential in the Functions of B Cell and Several Fc Receptors

  Immunity · 2000 · 10.1016/s1074-7613(00)00005-4

• SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis

  Cell · 1999 · 10.1016/s0092-8674(00)80049-5

• SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality

  Cell · 1999 · 10.1016/s0092-8674(00)80048-3

• Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors

  Cell · 1998 · https://doi.org/10.1016/s0092-8674(00)81167-8

Current projects

No projects listed.