Jacob H. Hanna

Research interests

Publications

• The N 6 -Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy

  Circulation · 2019 · 10.1161/circulationaha.118.036146

• Deciphering the “m6A Code” via Antibody-Independent Quantitative Profiling

  Cell · 2019 · 10.1016/j.cell.2019.06.013

• Human brain organoids on a chip reveal the physics of folding

  Nature Physics · 2018 · 10.1038/s41567-018-0046-7

• The Role of m6A/m-RNA Methylation in Stress Response Regulation

  Neuron · 2018 · 10.1016/j.neuron.2018.07.009

• m6A modification controls the innate immune response to infection by targeting type I interferons

  Nature Immunology · 2018 · 10.1038/s41590-018-0275-z

• m 6 A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover

  Genes & Development · 2017 · 10.1101/gad.301036.117

• Dynamic stem cell states: naive to primed pluripotency in rodents and humans

  Nature Reviews Molecular Cell Biology · 2016 · 10.1038/nrm.2015.28

• m 6 A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

  Science · 2015 · https://doi.org/10.1126/science.1261417

• SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate

  Cell · 2014 · 10.1016/j.cell.2014.12.013

• Derivation of novel human ground state naive pluripotent stem cells

  Nature · 2013 · 10.1038/nature12745

• Deterministic direct reprogramming of somatic cells to pluripotency

  Nature · 2013 · 10.1038/nature12587

• Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues

  Cell · 2010 · 10.1016/j.cell.2010.10.008

• Histone H3K27ac separates active from poised enhancers and predicts developmental state

  Proceedings of the National Academy of Sciences · 2010 · https://doi.org/10.1073/pnas.1016071107

• Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs

  Proceedings of the National Academy of Sciences · 2010 · 10.1073/pnas.1004584107

• Epigenetic memory in induced pluripotent stem cells

  Nature · 2010 · https://doi.org/10.1038/nature09342

• Reprogramming of Human Peripheral Blood Cells to Induced Pluripotent Stem Cells

  Cell stem cell · 2010 · 10.1016/j.stem.2010.06.002

• Direct cell reprogramming is a stochastic process amenable to acceleration

  Nature · 2009 · https://doi.org/10.1038/nature08592

• Reprogramming of murine and human somatic cells using a single polycistronic vector

  Proceedings of the National Academy of Sciences · 2008 · 10.1073/pnas.0811426106

• Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotency

  Cell · 2008 · 10.1016/j.cell.2008.03.028

• Genome-scale DNA methylation maps of pluripotent and differentiated cells

  Nature · 2008 · 10.1038/nature07107

• A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types

  Nature Biotechnology · 2008 · 10.1038/nbt1483

• Dissecting direct reprogramming through integrative genomic analysis

  Nature · 2008 · https://doi.org/10.1038/nature07056

• Treatment of Sickle Cell Anemia Mouse Model with iPS Cells Generated from Autologous Skin

  Science · 2007 · 10.1126/science.1152092

• Decidual NK cells regulate key developmental processes at the human fetal-maternal interface

  Nature Medicine · 2006 · 10.1038/nm1452

• Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1

  Nature Immunology · 2006 · 10.1038/ni1322

Current projects

No projects listed.