Itay Tirosh

Research interests

Publications

• Integrative spatial analysis reveals a multi-layered organization of glioblastoma

  Cell · 2024 · 10.1016/j.cell.2024.03.029

• Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours

  Nature · 2023 · 10.1038/s41586-023-06130-4

• Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma

  Cancer Cell · 2021 · 10.1016/j.ccell.2021.05.002

• Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis

  Cell · 2021 · 10.1016/j.cell.2021.01.022

• A single-cell landscape of high-grade serous ovarian cancer

  Nature Medicine · 2020 · 10.1038/s41591-020-0926-0

• The Glioma Stem Cell Model in the Era of Single-Cell Genomics

  Cancer Cell · 2020 · 10.1016/j.ccell.2020.04.001

• Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity

  Nature Genetics · 2020 · 10.1038/s41588-020-00726-6

• An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

  Cell · 2019 · https://doi.org/10.1016/j.cell.2019.06.024

• Single-Cell RNA Sequencing in Cancer: Lessons Learned and Emerging Challenges

  Molecular Cell · 2019 · 10.1016/j.molcel.2019.05.003

• Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

  Science · 2018 · https://doi.org/10.1126/science.aao4750

• T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

  Cell · 2018 · https://doi.org/10.1016/j.cell.2018.10.008

• A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

  Cell · 2018 · https://doi.org/10.1016/j.cell.2018.09.006

• Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0792-9

• Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer

  Cell · 2017 · 10.1016/j.cell.2017.10.044

• Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq

  Science · 2017 · 10.1126/science.aai8478

• A single-cell survey of the small intestinal epithelium

  Nature · 2017 · 10.1038/nature24489

• Challenges and emerging directions in single-cell analysis

  Genome biology · 2017 · 10.1186/s13059-017-1218-y

• Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

  Science · 2016 · 10.1126/science.aad0501

• Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

  Nature · 2016 · 10.1038/nature20123

• A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks

  Cell · 2015 · 10.1016/j.cell.2015.06.059

• Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

  Cell · 2015 · 10.1016/j.cell.2015.05.002

• Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells

  Genome Research · 2015 · 10.1101/gr.192237.115

• Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells

  Cell · 2014 · 10.1016/j.cell.2014.02.030

• A Yeast Hybrid Provides Insight into the Evolution of Gene Expression Regulation

  Science · 2009 · 10.1126/science.1169766

• Two strategies for gene regulation by promoter nucleosomes

  Genome Research · 2008 · 10.1101/gr.076059.108

Current projects

No projects listed.