Takeshi Iwatsubo

Research interests

Publications

• Lecanemab in Early Alzheimer’s Disease

  New England Journal of Medicine · 2022 · https://doi.org/10.1056/nejmoa2212948

• Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer's Disease

  The Journal of Prevention of Alzheimer s Disease · 2022 · https://doi.org/10.14283/jpad.2022.30

• The Amyloid-β Pathway in Alzheimer’s Disease

  Molecular Psychiatry · 2021 · https://doi.org/10.1038/s41380-021-01249-0

• World‐Wide FINGERS Network: A global approach to risk reduction and prevention of dementia

  Alzheimer s & Dementia · 2020 · https://doi.org/10.1002/alz.12123

• Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

  New England Journal of Medicine · 2014 · https://doi.org/10.1056/nejmoa1312889

• A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

  New England Journal of Medicine · 2013 · 10.1056/nejmoa1210951

• CSF biomarker variability in the Alzheimer's Association quality control program

  Alzheimer s & Dementia · 2013 · https://doi.org/10.1016/j.jalz.2013.01.010

• Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

  Journal of Neuropathology & Experimental Neurology · 2012 · https://doi.org/10.1097/nen.0b013e31825018f7

• Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

  Alzheimer s & Dementia · 2011 · https://doi.org/10.1016/j.jalz.2011.03.003

• Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

  Molecular Brain · 2008 · https://doi.org/10.1186/1756-6606-1-17

• Diagnosis and management of dementia with Lewy bodies

  Neurology · 2005 · https://doi.org/10.1212/01.wnl.0000187889.17253.b1

• Misfolded proteinase K–resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies

  Journal of Clinical Investigation · 2002 · https://doi.org/10.1172/jci200215777

• α-Synuclein is phosphorylated in synucleinopathy lesions

  Nature Cell Biology · 2002 · https://doi.org/10.1038/ncb748

• Misfolded proteinase K–resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies

  Journal of Clinical Investigation · 2002 · https://doi.org/10.1172/jci15777

• Hyperphosphorylation and insolubility of α‐synuclein in transgenic mouse oligodendrocytes

  EMBO Reports · 2002 · https://doi.org/10.1093/embo-reports/kvf109

• Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

  PubMed · 1998

Current projects

No projects listed.