Jerrold M. Olefsky

Research interests

Publications

• Inflammation in obesity, diabetes, and related disorders

  Immunity · 2022 · https://doi.org/10.1016/j.immuni.2021.12.013

• Exosomes as mediators of intercellular crosstalk in metabolism

  Cell Metabolism · 2021 · https://doi.org/10.1016/j.cmet.2021.08.006

• Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity

  Cell · 2017 · https://doi.org/10.1016/j.cell.2017.08.035

• Inflammatory mechanisms linking obesity and metabolic disease

  Journal of Clinical Investigation · 2017 · https://doi.org/10.1172/jci92035

• Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

  Nature Medicine · 2015 · https://doi.org/10.1038/nm.3760

• Macrophages, Immunity, and Metabolic Disease

  Immunity · 2014 · https://doi.org/10.1016/j.immuni.2014.05.010

• Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

  Nature Medicine · 2012 · https://doi.org/10.1038/nm.2885

• The cellular and signaling networks linking the immune system and metabolism in disease

  Nature Medicine · 2012 · https://doi.org/10.1038/nm.2627

• Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

  Cell Metabolism · 2012 · https://doi.org/10.1016/j.cmet.2012.04.001

• Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

  Gastroenterology · 2010 · https://doi.org/10.1053/j.gastro.2010.03.052

• GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

  Cell · 2010 · https://doi.org/10.1016/j.cell.2010.07.041

• Macrophages, Inflammation, and Insulin Resistance

  Annual Review of Physiology · 2010 · https://doi.org/10.1146/annurev-physiol-021909-135846

• Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

  Cell Metabolism · 2008 · https://doi.org/10.1016/j.cmet.2008.08.015

• Insulin sensitivity: modulation by nutrients and inflammation

  Journal of Clinical Investigation · 2008 · https://doi.org/10.1172/jci34260

• A Subpopulation of Macrophages Infiltrates Hypertrophic Adipose Tissue and Is Activated by Free Fatty Acids via Toll-like Receptors 2 and 4 and JNK-dependent Pathways

  Journal of Biological Chemistry · 2007 · https://doi.org/10.1074/jbc.m706762200

• Inflammation and insulin resistance

  FEBS Letters · 2007 · https://doi.org/10.1016/j.febslet.2007.11.057

• Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

  Nature · 2007 · https://doi.org/10.1038/nature06261

• IKK-β links inflammation to obesity-induced insulin resistance

  Nature Medicine · 2005 · https://doi.org/10.1038/nm1185

• Complex Distribution, Not Absolute Amount of Adiponectin, Correlates with Thiazolidinedione-mediated Improvement in Insulin Sensitivity

  Journal of Biological Chemistry · 2004 · https://doi.org/10.1074/jbc.m311113200

• Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle

  Proceedings of the National Academy of Sciences · 2003 · https://doi.org/10.1073/pnas.2536828100

• The Effect of Thiazolidinediones on Plasma Adiponectin Levels in Normal, Obese, and Type 2 Diabetic Subjects

  Diabetes · 2002 · https://doi.org/10.2337/diabetes.51.10.2968

• Acute and Chronic Effect of Insulin on Leptin Production in Humans: Studies In Vivo and In Vitro

  Diabetes · 1996 · https://doi.org/10.2337/diab.45.5.699

• Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes

  Diabetes · 1996 · https://doi.org/10.2337/diab.45.12.1661

• Improvement in Glucose Tolerance and Insulin Resistance in Obese Subjects Treated with Troglitazone

  New England Journal of Medicine · 1994 · https://doi.org/10.1056/nejm199411033311803

• Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp.

  Journal of Clinical Investigation · 1987 · https://doi.org/10.1172/jci112886

Current projects

No projects listed.